Nucleic Acid Vaccine-Induced Immune Responses Require CD28 Costimulation and Are Regulated by CTLA4

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Genetic immunization is a simple method for eliciting an immune response

1992 • 1,505 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.

1993 • 1,122 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization.

1997 • 566 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

1990 • 504 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

1995 • 481 citations

CTLA-4: a negative regulator of autoimmune disease.

1996 • 382 citations

Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells.

1996 • 353 citations

Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.

1997 • 307 citations

Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery

1996 • 305 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations.

1997 • 287 citations

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

1992 • 285 citations

Generation of MHC class I‐restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non‐muscle cells

1996 • 264 citations

The dominant role of bone marrow-derived cells in CTL induction following plasmid DNA immunization at different sites.

1997 • 257 citations

The immunobiology of muscle

1994 • 255 citations

Exposing the immunology of naked DNA vaccines

1995 • 254 citations

Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.

1996 • 245 citations

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis.

1996 • 232 citations

Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes

1997 • 226 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA

1997 • 149 citations

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction.

1998 • 137 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

Requirements for CD28-dependent T cell-mediated cytotoxicity.

1993 • 125 citations

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

1995 • 125 citations

B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.

1996 • 123 citations

Limited role of CD28-mediated signals in T helper subset differentiation.

1996 • 111 citations

Cutting Edge: CTLA-4 Ligation Delivers a Unique Signal to Resting Human CD4 T Cells That Inhibits Interleukin-2 Secretion but Allows Bcl-XL Induction

1998 • 111 citations

Immunomodulatory effects of a plasmid expressing B7‐2 on human immunodeficiency virus‐1‐specific cell‐mediated immunity induced by a plasmid encoding the viral antigen

1997 • 104 citations

Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability.

1997 • 87 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Activated T cells can induce high levels of CTLA-4 expression on B cells.

1995 • 78 citations

Protection against lethal toxic shock by targeted disruption of the CD28 gene.

1996 • 72 citations

B7 costimulation is necessary for the activation of the lytic function in cytotoxic T lymphocyte precursors.

1995 • 64 citations

Induction of Antigen-Specific Tumor Immunity by Genetic and Cellular Vaccines against MAGE: Enhanced Tumor Protection by Coexpression of Granulocyte-Macrophage Colony-Stimulating Factor and B7-1

1996 • 64 citations

DNA-Mediated Immunization and the Energetic Immune Response to Hepatitis B Surface Antigen

1995 • 60 citations

Antiviral immune responses in CTLA4 transgenic mice

1997 • 51 citations

Induction of autoimmunity in the absence of CD28 costimulation.

1996 • 49 citations

Mitogenic stimulation of T cells reveals differing contributions for B7‐1 (CD80) and B7‐2 (CD86) costimulation

1997 • 47 citations

Myoblasts fail to stimulate T cells but induce tolerance

1994 • 34 citations

Overview of DNA Vaccines

1995 • 32 citations

Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones.

1997 • 21 citations

Introduction of DNA into mammalian cells

1991 • 13 citations