Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

1990 • 745 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

1994 • 530 citations

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.

1995 • 528 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Acquisition of immunologic self-tolerance

1989 • 484 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen.

1962 • 386 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Antigen Analogs/MHC Complexes as Specific T Cell Receptor Antagonists

1994 • 195 citations

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

1989 • 143 citations

The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones.

1983 • 141 citations

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.

1994 • 119 citations

Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.

1995 • 103 citations

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation

1996 • 99 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing.

1995 • 87 citations

Significance of T-cell stimulation by altered peptide ligands in T cell biology

1995 • 66 citations

Altered protein tyrosine phosphorylation in anergic Th1 cells.

1993 • 65 citations

An intracellular calcium increase and protein kinase C activation fail to initiate T cell proliferation in the absence of a costimulatory signal.

1990 • 42 citations