Loss of HuR Is Linked to Reduced Expression of Proliferative Genes during Replicative Senescence

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs

1998 • 852 citations

Microarray analysis of replicative senescence

1999 • 741 citations

RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

1998 • 738 citations

Hypoxic Stabilization of Vascular Endothelial Growth Factor mRNA by the RNA-binding Protein HuR

1998 • 662 citations

HuR Regulates p21 mRNA Stabilization by UV Light

2000 • 534 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

The biology of replicative senescence

1997 • 511 citations

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

1989 • 481 citations

HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation

2000 • 441 citations

Role of redox-regulated transcription factors in inflammation, aging and age-related diseases

2000 • 299 citations

Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element

1999 • 294 citations

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes.

1993 • 277 citations

AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation

1996 • 258 citations

Expression genetics in cancer: Shifting the focus from DNA to RNA

1997 • 256 citations

ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system

1999 • 244 citations

Purification, Characterization, and cDNA Cloning of an AU-Rich Element RNA-Binding Protein, AUF1

1993 • 177 citations

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells.

1996 • 176 citations

Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes

1998 • 168 citations

Down-Regulation of Cyclin D1 Expression by Prostaglandin A₂ Is Mediated by Enhanced Cyclin D1 mRNA Turnover

2000 • 139 citations

Reversible Cellular Senescence: Implications for Immortalization of Normal Human Diploid Fibroblasts

1989 • 129 citations

Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 state.

1993 • 126 citations

老化ヒト二倍体線維芽細胞におけるG1サイクリン調節の変化 不活性サイクリンE‐Cdk2及びサイクリンD1‐Cdk2複合体

1993 • 115 citations

Inhibition of G₁ Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A₂

1996 • 113 citations

Differential Expression and Localization of the mRNA Binding Proteins, AU-Rich Element mRNA Binding Protein (AUF1) and Hu Antigen R (HuR), in Neoplastic Lung Tissue

2000 • 108 citations

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

1996 • 98 citations

Age-Dependent Modifications of Gene Expression in Human Fibroblasts

1998 • 90 citations

Increased granulocyte-macrophage colony-stimulating factor mRNA instability in cord versus adult mononuclear cells is translation- dependent and associated with increased levels of A + U-rich element binding factor

1996 • 86 citations

Replicative Senescence, Aging and Growth-Regulatory Transcription Factors

1996 • 76 citations

Global change of gene expression at late G1/S boundary may occur in human IMR‐90 diploid fibroblasts during senescence

1994 • 57 citations

Down-regulation of cdc2 in senescent human and hamster cells.

1991 • 46 citations

Collagenase production by early and late passage cultures of human fibroblasts

1989 • 45 citations

Decreased macrophage colony-stimulating factor mRNA expression from activated cord versus adult mononuclear cells: altered posttranscriptional stability

1994 • 38 citations

Characterization Of IGFBP-3, PAI-1 and SPARC mRNA expression in senescent fibroblasts

1996 • 34 citations

Regulation of Gene Expression and Transcription Factor Binding Activity during Cellular Aging

1996 • 33 citations

Decreased expression and activity of the immediate-early growth response (Egr-1) gene product during cellular senescence

1999 • 27 citations

Gene expression and aging

1993 • 23 citations

The Making and the Breaking of Senescence: Changes of Gene Expression During Cellular Aging and Immortalization

1998 • 19 citations

Changes in gene expression during senescence in culture

1992 • 19 citations