CD40 Signaling Replaces CD4+ Lymphocytes and Its Blocking Prevents Chronic Rejection of Heart Transplants

Dendritic cells and the control of immunity

1998 • 14,345 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Heart-Lung Transplantation

2016 • 2,165 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

The Role of CD40 Ligand in Costimulation and T‐Cell Activation

1996 • 441 citations

Requirement for CD40 Ligand in Costimulation Induction, T Cell Activation, and Experimental Allergic Encephalomyelitis

1996 • 425 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

1994 • 383 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

CD40-gp39 INTERACTIONS PLAY A CRITICAL ROLE DURING ALLOGRAFT REJECTION

1996 • 331 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand

1998 • 321 citations

Coronary atherosclerosis in transplanted mouse hearts. II. Importance of humoral immunity.

1994 • 259 citations

Immunologic basis of transplant-associated arteriosclerosis.

1996 • 214 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

The CD40 pathway in allograft rejection, acceptance, and tolerance

1997 • 180 citations

CD40-CD40 Ligand-Independent Activation of CD8+ T Cells Can Trigger Allograft Rejection

2000 • 153 citations

CD40 ligand is a T cell growth factor

1993 • 123 citations

ICAM-1 and B7-1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM-1

1999 • 120 citations

DENDRITIC CELLS AS REGULATORS OF IMMUNE REACTIVITY: IMPLICATIONS FOR TRANSPLANTATION1

1999 • 119 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

Cardiac Allograft Vasculopathy

1995 • 107 citations

CD40 and its crucial role as a member of the TNFR family

1998 • 104 citations

Reduced transplant arteriosclerosis in murine cardiac allografts placed in interferon-gamma knockout recipients.

1998 • 92 citations

CD40L: a multi-functional ligand

1993 • 84 citations

CD8+ T CELLS CONTRIBUTE TO THE DEVELOPMENT OF TRANSPLANT ARTERIOSCLEROSIS DESPITE CD154 BLOCKADE1

2000 • 77 citations

Recombinant CD40 ligand exerts potent biologic effects on T cells.

1994 • 77 citations

Heart transplants in interferon-gamma, interleukin 4, and interleukin 10 knockout mice. Recipient environment alters graft rejection.

1997 • 66 citations

Sustained Anti-CD4/CD8 Treatment Blocks Inflammatory Activation and Intimal Thickening in Mouse Heart Allografts

1997 • 66 citations

Accelerated graft coronary artery disease: diagnosis and prevention.

1992 • 46 citations

CD8+ LYMPHOCYTES AUGMENT CHRONIC REJECTION IN A MHC CLASS II MISMATCHED MODEL

2001 • 41 citations

CONTRIBUTION OF CD40-CD154-MEDIATED COSTIMULATION TO AN ALLORESPONSE IN VIVO1

1999 • 18 citations

Combined Blockade of CD28/B7 and CD40/CD40L Costimulatory Pathways Prevents the Onset of Chronic Rejection

1998 • 10 citations

Macrophages and transplant arteriosclerosis: known and novel molecules.

1995 • 9 citations

Contributions of cellular and humoral immunity to arteriopathic lesions in transplanted mouse hearts

1997 • 9 citations