Endocytosis, Recycling, and Degradation of the Insulin Receptor

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

The Insulin Receptor: Molecular Biology and Transmembrane Signaling*

1987 • 285 citations

Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.

1981 • 217 citations

On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell.

1981 • 198 citations

The fate of insulin bound to adipocytes. Evidence for compartmentalization and processing.

1978 • 189 citations

Insulin Receptor: Structure and Function

1981 • 187 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

Rapid, reversible internalization of cell surface insulin receptors. Correlation with insulin-induced down-regulation.

1983 • 159 citations

Insulin-induced loss of the insulin receptor in IM-9 lymphocytes. A biological process mediated through the insulin receptor.

1980 • 149 citations

Kinetics of insulin receptor internalization and recycling in adipocytes. Shunting of receptors to a degradative pathway by inhibitors of recycling.

1985 • 140 citations

Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation.

1982 • 139 citations

Surface binding and rates of internalization of 125I-insulin in adipocytes and IM-9 lymphocytes.

1982 • 116 citations

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

1987 • 110 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

Endocytosis of Peptide Hormones and Other Ligands

1982 • 90 citations

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

1987 • 89 citations

Biosynthesis and Processing of the Human Insulin Receptor

1986 • 59 citations

Down-regulation and recycling of insulin receptors. Effect of monensin on IM-9 lymphocytes and U-937 monocyte-like cells.

1984 • 51 citations

Receptor mediated endocytosis of polypeptide hormones: Mechanism and significance

1982 • 51 citations

Vanadate down-regulates cell surface insulin and growth hormone receptors and inhibits insulin receptor degradation in cultured human lymphocytes.

1988 • 46 citations

Insulin Internalization into Monocytes Is Decreased in Patients with Type II Diabetes Mellitus*

1986 • 38 citations

Insulin receptor cycling and insulin action in the rat adipocyte.

1985 • 31 citations

Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating (“Ksuper”) state of the insulin receptor

1988 • 29 citations

Intracellular Insulin Processing Is Altered in Monocytes from Patients with Type II Diabetes Mellitus

1987 • 18 citations

Rapid Effects of Insulin on the Cycling of the Insulin Receptor in a Human Monocyte Cell Line (U-937)

1985 • 11 citations

Co-capping of insulin, epidermal growth factor and concanavalin A surface receptors with each other and with cytoplasmic actin.

1980 • 3 citations