The selection of antibodies for targeted therapy of small-cell lung cancer (SCLC) using a human tumour spheroid model to compare the uptake of cluster 1 and cluster w4 antibodies

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors.

1989 • 257 citations

An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier".

1991 • 170 citations

Growth and Cellular Characteristics of Multicell Spheroids

1984 • 163 citations

Longevity in small cell lung cancer

1990 • 158 citations

Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids.

1987 • 150 citations

Neural cell adhesion molecule (NCAM) is the antigen recognized by monoclonal antibodies of similar specificity in small‐cell lung carcinoma and neuroblastoma

1989 • 133 citations

The Pharmacology of Monoclonal Antibodiesa

1987 • 129 citations

Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates.

1992 • 127 citations

Complete Tumor Ablation With Iodine 131-Radiolabeled Disialoganglioside GD2-Specific Monoclonal Antibody Against Human Neuroblastoma Xenografted in Nude Mice23

1986 • 117 citations

Interstitial transport of rabbit and sheep antibodies in normal and neoplastic tissues.

1990 • 108 citations

CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas

1993 • 104 citations

Ablation of human colon carcinoma in nude mice by 131I-labeled monoclonal anti-carcinoembryonic antigen antibody F(ab')2 fragments.

1989 • 67 citations

Relationship between tumour size and uptake of radiolabelled anti-CEA in a colon tumour xenograft

1987 • 64 citations

Determination of Equilibrium Binding Parameters of Monoclonal Antibodies Specific for Cell Surface Antigens

1981 • 59 citations

A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm

1991 • 55 citations

131I-meta-iodobenzylguanidine therapy in neuroblastoma spheroids of different sizes

1992 • 53 citations

Antigens of Lung Cancer: Results of the Second International Workshop on Lung Cancer Antigens

1991 • 52 citations

Uptake kinetics of monoclonal antibodies by human malignant melanoma multicell spheroids.

1988 • 41 citations

Immunolocalisation and imaging of small cell cancer xenografts by the IgG2a monoclonal antibody SWA11

1989 • 35 citations

Effect of polarity and differentiation on antibody localization in multicellular tumour spheroid and xenograft models and its potential importance for in vivo IMMUNOTARGETING

1989 • 31 citations

Use of multi‐cell spheroids of ovarian carcinoma as an intraperitoneal radio‐immunotherapy model: Uptake, retention kinetics and dosimetric evaluation

1992 • 31 citations

Diffusion and Binding of Monoclonal Antibody TNT-1 in Multicellular Tumor Spheroids

1991 • 26 citations

Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines

1992 • 24 citations

Biodistribution of a monoclonal antibody (RNL‐1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small‐cell lung‐cancer xenografts

1991 • 17 citations

Iodine-125-NRLU-10 kinetic studies and bismuth-212-NRLU-10 toxicity in LS174T multicell spheroids.

1990 • 16 citations

The Pharmacology of Monoclonal Antibodies

1994 • 16 citations

Effect of dose escalation of a monoclonal anti-CEA IgG on tumour localisation and tissue distribution in nude mice xenografted with human colon carcinoma

1986 • 16 citations

Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody

1988 • 15 citations

Selective immunotherapy of small cell cancer xenografts using 131I-labelled SWA11 antibody

1991 • 15 citations

Biodistribution and tumour localisation of 131I SWA11 recognising the cluster w4 antigen in patients with small cell lung cancer

1993 • 11 citations

Radiolocalization of human small cell lung cancer and antigen-positive normal tissues using monoclonal antibody LS2D617.

1990 • 7 citations

Radioimmunotherapy of transplanted small cell lung cancer with 131I-labelled monoclonal antibody

1989 • 1 citations