Delayed Human Immunodeficiency Virus Type 1-Induced Apoptosis in Cells Expressing Truncated Forms of CD4

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

1991 • 548 citations

Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.

1991 • 432 citations

YOPRO-1 permits cytofluorometric analysis of programmed cell death (apoptosis) without interfering with cell viability

1995 • 379 citations

The cytopathic effect of hiv is associated with apoptosis

1991 • 358 citations

Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

1992 • 251 citations

Lymphocyte activation by HIV-1 envelope glycoprotein

1988 • 224 citations

Immunopathogenesis of HIV infection

1991 • 213 citations

Membrane Expression of HIV Envelope Glycoproteins Triggers Apoptosis in CD4 Cells

1993 • 210 citations

Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4

1988 • 173 citations

Human immunodeficiency virus type 1 Vpu protein induces degradation of CD4 in vitro: the cytoplasmic domain of CD4 contributes to Vpu sensitivity

1993 • 134 citations

Apoptosis II: The Molecular Basis of Apoptosis in Disease

1994 • 126 citations

Programmed cell death (apoptosis) and cell survival regulation: relevance to AIDS and cancer

1994 • 111 citations

Envelope glycoproteins of human immunodeficiency virus type 1: profound influences on immune functions

1996 • 101 citations

Binding of Human Immunodeficiency Virus Type 1 to CD4 Induces Association of Lck and Raf-1 and Activates Raf-1 by a Ras-Independent Pathway

1996 • 83 citations

The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells.

1994 • 73 citations

Association of p56lck with the cytoplasmic domain of CD4 modulates HIV-1 expression.

1994 • 67 citations

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef

1993 • 66 citations

Rapid induction of apoptosis by cell-to-cell transmission of human immunodeficiency virus type 1

1995 • 64 citations

Productive infection and subsequent interaction of CD4-gp120 at the cellular membrane is required for HIV-induced apoptosis of CD4+ T cells

1995 • 62 citations

HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck.

1996 • 50 citations

HIV-1 Envelope Glycoproteins Induce Activation of Activated Protein-1 in CD4+ T Cells

1995 • 50 citations

Binding of HIV-1 virions or gp120-anti-gp120 immune complexes to HIV-1-infected quiescent peripheral blood mononuclear cells reveals latent infection.

1996 • 49 citations

Sequestration of p56(lck) by gp120, a model for TCR desensitization.

1997 • 46 citations

Several CD4 domains can play a role in human immunodeficiency virus infection in cells

1991 • 44 citations

Signals Transduced through the CD4 Molecule on T-Lymphocytes Activate NF-κB

1994 • 43 citations

Transduction of Activation Signal That Follows HIV-1 Binding to CD4 and CD4 Dimerization Involves the Immunoglobulin CDR3-like Region in Domain 1 of CD4

1997 • 37 citations

An early postinfection signal mediated by monoclonal anti-beta 2 microglobulin antibody is responsible for delayed production of human immunodeficiency virus type 1 in peripheral blood mononuclear cells

1990 • 31 citations

Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule

1996 • 29 citations

HIV-1 envelope glycoproteins-mediated apoptosis is regulated by CD4 dependent and independent mechanisms

1997 • 26 citations

HIV-1 gp120/160 expressing cells upregulate HIV-1 LTR directed gene expression in a cell line transfected with HIV-1 LTR-reporter gene constructs.

1995 • 20 citations

Cell fusion mediated by interaction of a hybrid CD4.CD8 molecule with the human immunodeficiency virus type 1 envelope glycoprotein does occur after a long lag time

1993 • 18 citations

An Anti-CD4 (CDR3-Loop) Monoclonal Antibody Inhibits Human Immunodeficiency Virus Type 1 Envelope Glycoprotein-Induced Apoptosis

1998 • 13 citations

Membrane Anchorage of gp160 Is Necessary and Sufficient to Prevent CD4 Transport to the Cell Surface

1996 • 9 citations