Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

2002 • 18,672 citations

Multidrug resistance in cancer: role of ATP–dependent transporters

2002 • 5,195 citations

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

Targeting multidrug resistance in cancer

2006 • 3,410 citations

Drug penetration in solid tumours

2006 • 2,562 citations

Mechanisms of Cancer Drug Resistance

2002 • 2,495 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Identifying differentially expressed genes using false discovery rate controlling procedures

2003 • 1,741 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

2004 • 976 citations

Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm

1989 • 943 citations

Functional variants of OCTN cation transporter genes are associated with Crohn disease

2004 • 841 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Active transport of imatinib into and out of cells: implications for drug resistance

2004 • 650 citations

The SLC22 drug transporter family

2004 • 519 citations

Predicting drug sensitivity and resistance

2004 • 517 citations

Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

1997 • 454 citations

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

2007 • 451 citations

Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2

2005 • 433 citations

Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity

2006 • 421 citations

LST-2, A human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers

2001 • 338 citations

Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)

2006 • 331 citations

Neural Computing in Cancer Drug Development: Predicting Mechanism of Action

1992 • 301 citations

Membrane Transporters and Channels

2004 • 277 citations

Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells

2004 • 247 citations

The Copper Transporter CTR1 Regulates Cisplatin Uptake in Saccharomyces cerevisiae

2002 • 227 citations

Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells

2005 • 221 citations

Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.

1995 • 215 citations

The Organic Anion Transporter (OATP) Family

2004 • 196 citations

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

2006 • 177 citations

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel

2006 • 170 citations

Etoposide: Discovery and Medicinal Chemistry

2004 • 167 citations

Characterization of the organic cation transporter SLC22A16: A doxorubicin importer

2005 • 145 citations

Uptake of Cardiovascular Drugs Into the Human Heart

2006 • 112 citations

Comparing cDNA and oligonucleotide array data: concordance of gene expression across platforms for the NCI-60 cancer cells

2003 • 109 citations

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

2007 • 96 citations

Spotlight on molecular profiling: “Integromic” analysis of the NCI-60 cancer cell lines

2006 • 95 citations

Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations

2007 • 69 citations