Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen.

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

1992 • 1,227 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

1992 • 694 citations

Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease

1991 • 686 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis

1994 • 511 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.

1994 • 316 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Principles for Adoptive T Cell Therapy of Human Viral Diseases

1995 • 256 citations

Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes

1999 • 242 citations

The Multi-epitope Approach for Immunotherapy for Cancer: Identification of Several CTL Epitopes from Various Tumor-Associated Antigens Expressed on Solid Epithelial Tumors

1998 • 235 citations

Identification of Ny-Eso-1 Epitopes Presented by Human Histocompatibility Antigen (Hla)-Drb4*0101–0103 and Recognized by Cd4+T Lymphocytes of Patients with Ny-Eso-1–Expressing Melanoma

2000 • 232 citations

Melanoma Cells Present a MAGE-3 Epitope to CD4+ Cytotoxic T Cells in Association with Histocompatibility Leukocyte Antigen DR11

1999 • 231 citations

Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

1996 • 201 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.

1997 • 188 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Biochemical Identification of a Mutated Human Melanoma Antigen Recognized by CD4+ T Cells

1999 • 178 citations

Identification of New HER2/neu-Derived Peptide Epitopes That Can Elicit Specific CTL Against Autologous and Allogeneic Carcinomas and Melanomas

1999 • 176 citations

HER2/neu-derived peptides are shared antigens among human non-small cell lung cancer and ovarian cancer.

1994 • 174 citations

Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.

1984 • 174 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

Melan-A/MART-1_51–73represents an immunogenic HLA-DR4-restricted epitope recognized by melanoma-reactive CD4⁺T cells

2000 • 160 citations

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

1984 • 152 citations

In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein.

1994 • 150 citations

Specificity of OKT4+ cytotoxic T lymphocyte clones.

1982 • 136 citations

Exploration of requirements for peptide binding to HLA DRB1*0101 and DRB1*0401.

1994 • 127 citations

Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells.

1999 • 127 citations

Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell Srfaces

1990 • 122 citations

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1988 • 107 citations

Identification of Her-2/Neu CTL epitopes using double transgenic mice expressing HLA-A2.1 and human CD.8

1997 • 107 citations

Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte

1999 • 101 citations

MHC class II restricted tumor antigens and the role of CD4+ T cells in cancer immunotherapy

1994 • 98 citations

Identification of HER2/neu-derived peptide epitopes recognized by gastric cancer-specific cytotoxic T lymphocytes

1998 • 94 citations

Naturally processed class II epitope from the tumor antigen MUC1 primes human CD4+ T cells.

1998 • 85 citations

Recognition of rabies and rabies-related viruses by T cells derived from human vaccine recipients

1988 • 74 citations

CD4+ T cells from peripheral blood of a melanoma patient recognize peptides derived from nonmutated tyrosinase.

1998 • 68 citations

Hepatitis B virus-reactive human T lymphocyte clones: antigen specificity and helper function for antibody synthesis.

1984 • 66 citations

Structural requirements for the interaction between peptide antigens and I-Ed molecules.

1989 • 65 citations

Evidence that HLA class II-restricted human CD4+ T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms

1998 • 60 citations

Identification of GP100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primaryin vitro immunization with peptide-pulsed dendritic cells

1998 • 51 citations

Specific T Cell Recognition of Peptides Derived from Prostate-specific Antigen in Patients with Prostate Cancer

1998 • 49 citations

Proliferative and cytokine responses to class II HER-2/neu-associated peptides in breast cancer patients.

1998 • 48 citations

Existent proliferative responses of peripheral blood mononuclear cells from healthy donors and ovarian cancer patients to HER-2 peptides.

1997 • 40 citations

Identification of a MAGE-2-encoded human leukocyte antigen-A24-binding synthetic peptide that induces specific antitumor cytotoxic T lymphocytes.

1999 • 36 citations

Two distinct HLA-A * 0101-specific submotifs illustrate alternative peptide binding modes

1997 • 34 citations