Peripheral T‐Cell Reactivity to Bacterial Superantigens in vivo: The Response/Anergy Paradox

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses

1991 • 783 citations

Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins

1989 • 711 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.

1992 • 595 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells.

1988 • 427 citations

A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus

1991 • 394 citations

High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR

1989 • 388 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior^#

1989 • 337 citations

Clonal expansion precedes anergy and death of V_β8⁺ peripheral T cells responding to staphylococcal enterotoxin B in vivo

1991 • 330 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Crystal structure of staphylococcal enterotoxin B, a superantigen

1992 • 304 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

1990 • 301 citations

Class II MHC Molecules Are Specific Receptors for Staphylococcus Enterotoxin A

1989 • 267 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Mls — a retrovirus exploits the immune system

1991 • 233 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Peripheral Clonal Elimination of Functional T Cells

1990 • 213 citations

Mutations defining functional regions of the superantigen staphylococcal enterotoxin B.

1992 • 208 citations

Viral receptors of the immunoglobulin superfamily

1989 • 178 citations

Infection breaks T-cell tolerance

1992 • 174 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines.

1989 • 169 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice.

1992 • 149 citations

An exogenous mouse mammary tumor virus with properties of Mls-1a (Mtv-7).

1992 • 136 citations

Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins.

1990 • 132 citations

Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity.

1993 • 122 citations

Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class ii isotypes

1989 • 118 citations

Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E.

1992 • 116 citations

In vivo responses of CD4⁺ and CD8⁺ cells to bacterial superantigens

1992 • 109 citations

Memory T cells are anergic to the superantigen staphylococcal enterotoxin B.

1992 • 92 citations

Exogenous and Endogenous Mouse Mammary Tumor Virus Superantigens

1993 • 77 citations

Oligoclonal expansion of major histocompatibility complex class I-restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction.

1993 • 76 citations

Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses.

1992 • 75 citations

Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines

1993 • 72 citations

Expansion and clonal deletion of peripheral T cells induced by bacterial superantigen is independent of the interleukin‐2 pathway

1992 • 70 citations

Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells.

1990 • 68 citations

Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation.

1992 • 64 citations

Life and death of a superantigen-reactive human CD4⁺ T cell clone: staphylococcal enterotoxins induce death by apoptosis but simultaneously trigger a proliferative response in the presence of HLA-DR⁺ antigen-presenting cells

1992 • 63 citations

T-Cell Recognition of Minor Lymphocyte Stimulating (MLS) Gene Products

1989 • 59 citations

Pgp-1 (Ly 24) As a Marker of Murine Memory T Lymphocytes

1990 • 58 citations

A recombinant C-terminal fragment of staphylococcal enterotoxin A binds to human MHC class II products but does not activate T cells.

1991 • 52 citations

Cyclosporin A markedly enhances superantigen-induced peripheral T cell deletion and inhibits anergy induction.

1992 • 52 citations

In vivo induction of apoptosis in immature thymocytes by staphylococcal enterotoxin B.

1992 • 48 citations

In vivo administration of interleukin‐2 turns on anergic self‐reactive T cells and leads to autoimmune disease

1992 • 44 citations

Proliferative T cell anergy to MIs-1^a does not correlate with in vivo tolerance

1991 • 37 citations

Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity

1991 • 36 citations

Skewed T cell receptor V_α repertoire among superantigen reactive murine T cells

1993 • 36 citations

T Cell Recognition of Superantigens

1991 • 34 citations

The CD8 T cell response to staphylococcal enterotoxins

1993 • 29 citations

Peripheral clonal deletion of superantigen‐reactive T cells is enhanced by cortisone

1993 • 24 citations

Newly generated thymocytes are not refractory to deletion when the α/β component of the T cell receptor is engaged by the superantigen staphylococcal enterotoxin B

1990 • 20 citations

Staphylococcal-enterotoxin-dependent cell-mediated cytotoxicity

1991 • 5 citations