Helicobacter pylori: resurrection of the cancer link

THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO‐CALLED INTESTINAL‐TYPE CARCINOMA

1965 • 5,842 citations

UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION

1984 • 5,344 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Helicobacter pyloriInfection and the Development of Gastric Cancer

2001 • 4,276 citations

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

2000 • 4,020 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

1999 • 3,031 citations

Interleukin-1 polymorphisms associated with increased risk of gastric cancer

2000 • 2,355 citations

Rising Incidence of Adenocarcinoma of the Esophagus and nGastric Cardia

1991 • 2,278 citations

Cancer burden in the year 2000. The global picture

2001 • 2,206 citations

Changing patterns in the incidence of esophageal and gastric carcinoma in the United States

1998 • 2,080 citations

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

1995 • 1,551 citations

Organization and regulation of mitogen-activated protein kinase signaling pathways

1999 • 1,288 citations

Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

1998 • 1,182 citations

Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens

1993 • 1,172 citations

A MODEL FOR GASTRIC CANCER EPIDEMIOLOGY

1975 • 1,091 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer

1998 • 956 citations

Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

2002 • 877 citations

Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori

1999 • 772 citations

Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis

1997 • 712 citations

Essential role of urease in pathogenesis of gastritis induced by Helicobacter pylori in gnotobiotic piglets

1991 • 693 citations

Relationship Between Cancer of Stomach and the ABO Blood Groups

1953 • 667 citations

Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology

1991 • 667 citations

Helicobacter pylori infection and chronic gastric acid hyposecretion

1997 • 646 citations

The prevalence of Helicobacter pylori infection in different countries.

1995 • 615 citations

Free recombination within Helicobacter pylori

1998 • 591 citations

Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin

1999 • 591 citations

Tyrosine phosphorylation of theHelicobacter pyloriCagA antigen aftercag-driven host cell translocation

2000 • 585 citations

Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains.

1995 • 534 citations

An inverse relation between cagA+ strains of Helicobacter pylori infection and risk of esophageal and gastric cardia adenocarcinoma.

1998 • 534 citations

Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy

2000 • 508 citations

Familial gastric cancer: overview and guidelines for management.

1999 • 494 citations

Cancer Incidence and Mortality Trends Among Whites in the United States, 1947–84

1987 • 455 citations

An Essential Role for DNA Adenine Methylation in Bacterial Virulence

1999 • 453 citations

Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease

1987 • 446 citations

Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection

2001 • 430 citations

Epidemiology of Helicobacter pylori in Southern China: Identification of Early Childhood as the Critical Period for Acquisition

1992 • 430 citations

Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma

2001 • 429 citations

Trends in cancer incidence and mortality

1994 • 427 citations

Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells

1997 • 413 citations

Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori

2001 • 401 citations

Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites

1990 • 400 citations

Association of Helicobacter Pylori Infection With Gastric Carcinoma: A Meta-Analysis

1999 • 397 citations

The incidence of Helicobacter pylori infection.

1995 • 393 citations

The seroprevalence of cagA-positive Helicobacter pylori strains in the spectrum of gastroesophageal reflux disease

1998 • 390 citations

Helicobacter pylori genetic diversity and risk of human disease

2001 • 377 citations

Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.

1995 • 360 citations

Interleukin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan

2002 • 348 citations

Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa

1996 • 332 citations

Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.

1998 • 330 citations

Phenotypic and genotypic events in gastric carcinogenesis.

1994 • 329 citations

Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses

2001 • 326 citations

Local Cytokine Response inHelicobacter pylori-Infected Subjects

1998 • 324 citations

Genetic susceptibility and gastric cancer risk

2002 • 317 citations

Science, medicine, and the future: Helicobacter pylori and gastric diseases

1998 • 302 citations

Helicobacter heilmannii–associated primary gastric low-grade MALT lymphoma: Complete remission after curing the infection

2000 • 297 citations

Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori

1992 • 294 citations

Epithelial attachment alters the outcome of Helicobacter pylori infection

1998 • 294 citations

Transmission of Helicobacter pylori among siblings

2000 • 287 citations

Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins.

1996 • 287 citations

E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer

1999 • 286 citations

Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil

2000 • 285 citations

Interleukin 1β and tumour necrosis factor α inhibit acid secretion in cultured rabbit parietal cells by multiple pathways

1998 • 280 citations

Review article: exploring the link between Helicobacter pylori and gastric cancer

1999 • 278 citations

A microfabricated device for sizing and sorting DNA molecules

1999 • 276 citations

Differential Activation of Mitogen-Activated Protein Kinases in AGS Gastric Epithelial Cells bycag+ andcag− Helicobacter pylori

1999 • 275 citations

Gastric Dysplasia and Gastric Cancer: Helicobacter pylori, Serum Vitamin C, and Other Risk Factors

2000 • 268 citations

An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium.

1993 • 264 citations

Gastric Interleukin‐8 and IgA IL‐8 Autoantibodies in Helicobacter pylori Infection

1993 • 262 citations

Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel.

1999 • 247 citations

The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy

1998 • 241 citations

Seroprevalence of Helicobacter pylori Infections in Thailand

1990 • 228 citations

The epidemiology of Helicobacter pylori in Peruvian children between 6 and 30 months of age.

1994 • 223 citations

Vacuolating Cytotoxin of Helicobacter pylori Plays a Role during Colonization in a Mouse Model of Infection

2001 • 220 citations

Evaluating Gastric Cancer Misclassification: a Potential Explanation for the Rise in Cardia Cancer Incidence

1999 • 217 citations

Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.

1993 • 214 citations

Helicobacter pyloriamong Preschool Children and Their Parents: Evidence of Parent‐Child Transmission

1999 • 213 citations

Seroepidemiology of Helicobacter pylori infection in a cohort of children monitored from 6 months to 11 years of age

1997 • 212 citations

Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue.

1989 • 211 citations

Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori

1993 • 210 citations

Induction of host signal transduction pathways by Helicobacter pylori

1997 • 202 citations

DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity

1999 • 196 citations

Epidemiology of intestinal and diffuse types of gastric carcinoma a time-trend study in finland with comparison between studies from high- and low-risk areas

1993 • 192 citations

Features of gastric cancer in hereditary non-polyposis colorectal cancer syndrome

1997 • 190 citations

Complete Remission of Primary High-Grade B-Cell Gastric Lymphoma After Cure of Helicobacter pylori Infection

2001 • 190 citations

Case‐control study on stomach cancer in Germany

1991 • 189 citations

Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying

1991 • 187 citations

Esophageal and gastric carcinoma in Norway 1958-1992: Incidence time trend variability according to morphological subtypes and organ subsites

1997 • 178 citations

Simultaneous Expression of Type 1 and Type 2 Lewis Blood Group Antigens by Helicobacter pyloriLipopolysaccharides

1998 • 177 citations

Activation of Activator Protein 1 and Stress Response Kinases in Epithelial Cells Colonized by Helicobacter pylori Encoding the cag Pathogenicity Island

1999 • 176 citations

Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation.

2001 • 170 citations

Increasing incidence of both major histological types of esophageal carcinomas among men in Sweden

1993 • 167 citations

Review article: pathogenesis of Helicobacter pylori‐induced gastric inflammation

2001 • 160 citations

Epidemiology of Infection

2014 • 158 citations

Proteins Encoded by thecagPathogenicity Island ofHelicobacter pyloriAre Required for NF-κB Activation

1998 • 157 citations

Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells

2002 • 157 citations

Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

1997 • 156 citations

Effects of Helicobacter pyloriinfection on gastric acid secretion and serum gastrin levels in Mongolian gerbils

2001 • 154 citations

Association of the interleukin-1 * genetic polymorphism and gastric cancer risk in Japanese

2001 • 152 citations

Helicobacter pylori infection in children: relation with current household living conditions.

1996 • 148 citations

Increasing incidence of carcinoma of the gastric cardia in Sweden from 1970 to 1985

1993 • 144 citations

Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains

1998 • 140 citations

Dynamics of epithelial cells in the corpus of the mouse stomach. V. Behavior of entero‐endocrine and caveolated cells: General conclusions on cell kinetics in the oxyntic epithelium

1993 • 135 citations

Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations

1999 • 133 citations

Expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of FVB/N mouse stomach results in production of Leb-containing glycoconjugates: a potential transgenic mouse model for studying Helicobacter pylori infection.

1995 • 132 citations

Clinical Relevance of the babA2 Genotype of Helicobacter pylori in Japanese Clinical Isolates

2001 • 127 citations

The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced byHelicobacter pylori infection

1998 • 126 citations

Helicobacter pylori infection in Swedish school children: Lack of evidence of child-to-child transmission outside the family

2001 • 126 citations

Molecular Cloning and Expression of Rat Squalene Epoxidase

1995 • 125 citations

Comparison of Genetic Divergence and Fitness between Two Subclones of Helicobacter pylori

2001 • 124 citations

Colonization with <i>cag</i>A-Positive <i>Helicobacter pylori</i> Strains Inversely Associated with Reflux Esophagitis and Barrett’s Esophagus

2000 • 115 citations

Dynamics of Helicobacter pylori colonization in relation to the host response

1999 • 114 citations

A follow-up study of atrophic gastritis and intestinal metaplasia after eradication of Helicobacter pylori.

1998 • 113 citations

Time trends of intestinal and diffuse types of gastric cancer in Norway

1971 • 112 citations

p21-activated Kinase 1 Activates the Nuclear Factor κB (NF-κB)-inducing Kinase-IκB Kinases NF-κB Pathway and Proinflammatory Cytokines in Helicobacter pyloriInfection

2000 • 110 citations

Helicobacter pylori strain types and risk of gastric cancer: a case-control study.

2000 • 107 citations

A low rate of reinfection following effective therapy against Helicobacter pylori in a developing nation (China)

1998 • 102 citations

Time trends of intestinal and diffuse types of gastric cancer in the United States

1971 • 102 citations

Decreasing incidence of both major histologic subtypes of gastric adenocarcinoma – a population-based study in Sweden

2000 • 102 citations

Gastrin secretion from primary cultures of rabbit antral G cells: Stimulation by inflammatory cytokines

1996 • 100 citations

Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori

1996 • 100 citations

Functional impairment of rat enterochromaffin-like cells by interleukin 1 beta

1997 • 99 citations

Helicobacter pylori infection occurs via close contact with infected individuals in early childhood

2000 • 99 citations

MUC1 gene polymorphism and gastric cancer--an epidemiological study.

1997 • 99 citations

A Century of Helicobacter pylori

1998 • 97 citations

Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori.

2001 • 93 citations

Central action of recombinant interleukin-1 to inhibit acid secretion in rats

1990 • 88 citations

Helicobacter pylori : Clonal Population Structure and Restricted Transmission within Families Revealed by Molecular Typing

2000 • 86 citations

The long‐term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis

2002 • 86 citations

Association of gastric adenocarcinoma with the HLA class II gene DQB10301

1996 • 86 citations

High prevalence of Helicobacter pylori infection in cohabiting children. Epidemiology of a cluster, with special emphasis on molecular typing.

1994 • 85 citations

Helicobacter pyloriReinfection Is Virtually Absent after Successful Eradication

1997 • 84 citations

Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle

2006 • 83 citations

An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

1995 • 83 citations

cagA positive and negative Helicobacter pyloristrains are simultaneously present in the stomach of most patients with non-ulcer dyspepsia: relevance to histological damage

1998 • 80 citations

Cytokine inhibition of gastric acid secretion—A little goes a long way

1992 • 79 citations

A Framework for the Aetiogenesis of Chronic Pancreatitis

1998 • 79 citations

Incidence of cancer of oesophagus, cardia and stomach in Denmark

1992 • 77 citations

Helicobacter pylori Attaches to NeuAcα2,3Galβ1,4 Glycoconjugates Produced in the Stomach of Transgenic Mice Lacking Parietal Cells

1999 • 76 citations

Evidence from a Nine-Year Birth Cohort Study in Japan of Transmission Pathways of Helicobacter pylori Infection

2000 • 74 citations

Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue

1999 • 73 citations

Family history and risk of stomach cancer in Warsaw, Poland

1999 • 72 citations

Epidemiological Characteristics of Adenocarcinoma of the Gastric Cardia and Distal Stomach in the United States, 1973–1982

1988 • 66 citations

Helicobacter pylori: molecular evolution of a bacterial quasi-species

1998 • 66 citations

High prevalence of Helicobacter pylori antibodies in an institutionalized population: evidence for person-to-person transmission.

1995 • 66 citations

Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1β

2001 • 66 citations

Helicobacter pylori Entry into Human Gastric Epithelial Cells: A Potential Determinant of Virulence, Persistence, and Treatment Failures ¹

2000 • 65 citations

Signal transduction–mediated adherence and entry of Helicobacter pylori into cultured cells

1999 • 65 citations

Is the Sanctuary WhereHelicobacter pyloriAvoids Antibacterial Treatment Intracellular?

1997 • 63 citations

Guillain‐Barré Syndrome: Multifactorial Mechanisms versus Defined Subgroups

1997 • 58 citations

Co-twin Study of the Effect of Environment and Dietary Elements on Acquisition of Helicobacter pylori Infection

1998 • 58 citations

Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer.

2002 • 57 citations

Colonization of Germ-free Transgenic Mice with Genotyped Helicobacter pylori Strains from a Case-Control Study of Gastric Cancer Reveals a Correlation between Host Responses and HsdS Components of Type I Restriction-Modification Systems

2002 • 57 citations

Essential role of Helicobacter pylori urease in gastric colonization: definite proof using a urease-negative mutant constructed by gene replacement.

1994 • 56 citations

Blood type and family cancer history in relation to precancerous gastric lesions

2000 • 54 citations

Decreased Incidences of Intestinal and Diffuse Types of Gastric Carcinoma in Finland during a 20-Year Period

1987 • 50 citations

Pathology of Gastritis and Peptic Ulceration

2014 • 50 citations

One stomach--one strain: does Helicobacter pylori strain variation influence disease outcome?

1999 • 47 citations

High prevalence of mixed infections by Helicobacter pylori in Hong Kong: metronidazole sensitivity and overall genotype

2001 • 46 citations

IL-1β–Induced apoptosis in rat gastric enterochromaffin-like cells is mediated by iNOS, NF-κB, and Bax protein

2000 • 45 citations

Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis

2002 • 43 citations

Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis

1999 • 42 citations

Predominantly tumor-limited expression of a mutant allele in a Japanese family carrying a germline p53 mutation.

1994 • 40 citations

Theoretical and experimental approaches for studying factors defining the Helicobacter pylori–host relationship

2000 • 39 citations

Helicobacter pylori: Evidence for spouse‐to‐spouse transmission

1999 • 35 citations

Recent time trends in cancer of the oesophagus and gastric cardia in the region of Calvados in France, 1978–1995

1999 • 32 citations

Effects of interleukin-8 and Helicobacter pylori on histamine release from isolated canine gastric mucosal mast cells

2002 • 31 citations

Role of Corpus Gastritis and cagA -Positive Helicobacter pylori Infection in Reflux Esophagitis

2002 • 29 citations

Genotypes of Helicobacter pylori in Lithuanian families.

1998 • 28 citations

MUC6 gene polymorphism in healthy individuals and in gastric cancer patients from northern Portugal.

1997 • 26 citations

Helicobacter pylori Antibody Profile in Household Members of Children with H. pylori Infection

1999 • 23 citations

Modes of adherence of Helicobacter pylori to gastric surface epithelium in gastroduodenal disease: A possible sequence of events leading to internalisation

2000 • 23 citations

Histological and functional recovery in patients with multifocal atrophic gastritis after eradication of Helicobacter pylori infection.

1999 • 22 citations

Bacterium–host interactions monitored by time-lapse photography

1997 • 22 citations

Interleukin-1 beta acts at hypothalamic sites to inhibit gastric acid secretion in rats

1992 • 22 citations

Association of polymorphisms of interleukin-1 beta gene and Helicobacter pylori infection with the risk of gastric ulcer.

2002 • 21 citations

Intestinal and diffuse types of gastric cancer: secular trends in Sweden since 1951

1991 • 21 citations

Central interleukin-1β-induced inhibition of acid secretion in rats: Specificity of action

1993 • 17 citations

ThecagPathogenicity Island

2014 • 17 citations

16. Malignant tumours of the stomach

1992 • 14 citations

Intestinal type: diffuse type ratio of gastric carcinoma in a Mexican population.

1997 • 14 citations

Helicobacter pylori and impaired gastric secretory functions associated with duodenal ulcer and atrophic gastritis.

1997 • 14 citations

Vacuolating Cytotoxin

2014 • 11 citations

Pro-inflammatory genotypes of IL-1β, TNF-α and IL-10 increase risk of distal gastric cancer but not of cardia or oesophageal adenocarcinomas

2001 • 9 citations

Deleted Work

1955 • 0 citations