Helicobacter pylori strain types and risk of gastric cancer: a case-control study.

cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

1996 • 1,883 citations

Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.

1995 • 1,613 citations

Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

1995 • 1,551 citations

Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.

1997 • 962 citations

Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer

1998 • 956 citations

Analyses of the cag pathogenicity island of Helicobacter pylori

1998 • 714 citations

Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production

1993 • 671 citations

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

1997 • 649 citations

The Risk of Stomach Cancer in Patients with Gastric or Duodenal Ulcer Disease

1996 • 629 citations

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin

1995 • 594 citations

Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk.

1995 • 412 citations

Expanding Allelic Diversity of Helicobacter pylori vacA

1998 • 280 citations

Diversity of Helicobacter pylori vacA and cagA Genes and Relationship to VacA and CagA Protein Expression, Cytotoxin Production, and Associated Diseases

1998 • 210 citations

H. pylori and cagA: Relationships with Gastric Cancer, Duodenal Ulcer, and Reflux Esophagitis and Its Complications

1998 • 176 citations

Helicobacter pylori Infection and Risk of Cardia Cancer and Non-Cardia Gastric Cancer: A Nested Case-Control Study

1999 • 162 citations

Did the inheritance of a pathogenicity island modify the virulence of Helicobacter pylori?

1997 • 156 citations

Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma.

1997 • 126 citations

Atrophic Gastritis and Intestinal Metaplasia in Helicobacter pylori Infection: The role of CagA status

1998 • 96 citations

Helicobacter pylori cagA Status and s and m Alleles of vacA in Isolates from Individuals with a Variety of H. pylori -Associated Gastric Diseases

1998 • 75 citations

Helicobacter pylori infection and cancer

1998 • 64 citations

One stomach--one strain: does Helicobacter pylori strain variation influence disease outcome?

1999 • 47 citations

Relation between Histologic Subtypes and Location of Gastric Cancer andHelicobacter pylori

1997 • 43 citations

Cytotoxin-Associated Gene A-PositiveHelicobacter pylori Infection in the Elderly

1998 • 30 citations

A review of the possible bacterial determinants of clinical outcome inHelicobacter pyloriinfection

1998 • 12 citations