cag , a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

1991 • 3,869 citations

Current protocols in molecular biology

1988 • 2,473 citations

Advanced bacterial genetics

1980 • 2,388 citations

Helicobacter pylori Infection and Gastric Lymphoma

1994 • 1,845 citations

Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

1995 • 1,551 citations

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer.

1993 • 1,262 citations

A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

1995 • 1,239 citations

Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells.

1989 • 988 citations

Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.

1996 • 793 citations

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 • 594 citations

Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin

1995 • 594 citations

Development of a Mouse Model of Helicobacter pylori Infection that Mimics Human Disease

1995 • 574 citations

Excision of large DNA regions termed pathogenicity islands from tRNA-specific loci in the chromosome of an Escherichia coli wild-type pathogen

1994 • 412 citations

Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro

1995 • 393 citations

Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL‐8 in gastric epithelial cells

1995 • 393 citations

Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.

1995 • 360 citations

hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes

1995 • 350 citations

Membrance traffic wardens and protein secretion in Gram-negative bacteria

1993 • 346 citations

CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines.

1994 • 325 citations

Molecular characterization of an operon required for pertussis toxin secretion.

1993 • 307 citations

Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extra intestinal Escherichia coli isolates

1990 • 302 citations

Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri.

1993 • 269 citations

Contact with epithelial cells induces the formation of surface appendages on Salmonella typhimurium

1994 • 264 citations

Gastric Interleukin‐8 and IgA IL‐8 Autoantibodies in Helicobacter pylori Infection

1993 • 262 citations

The Interrelationship between Cytotoxin-Associated Gene A, Vacuolating Cytotoxin, and Helicobacter pylori-Related Diseases

1996 • 256 citations

Loss of the pigmentation phenotype in Yersinia pestis is due to the spontaneous deletion of 102 kb of chromosomal DNA which is flanked by a repetitive element

1992 • 244 citations

Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis

1981 • 240 citations

Conservation of secretion pathways for pathogenicity determinants of plant and animal bacteria

1993 • 226 citations

Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange

1993 • 216 citations

Common mechanisms in bacterial conjugation and Ti-mediated T-DNA transfer to plant cells

1994 • 214 citations

Characterization of the virB operon from an Agrobacterium tumefaciens Ti plasmid.

1988 • 190 citations

Adaptation of a conjugal transfer system for the export of pathogenic macromolecules

1996 • 188 citations

Induction of interleukin-8 secretion from gastric epithelial cells by a cagA negative isogenic mutant of Helicobacter pylori.

1995 • 165 citations

The virulence gene cluster of Listeria monocytogenes is also present in Listeria ivanovii, an animal pathogen, and Listeria seeligeri, a nonpathogenic species

1994 • 152 citations

Large, unstable inserts in the chromosome affect virulence properties of uropathogenic Escherichia coli O6 strain 536

1986 • 138 citations

Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori

1994 • 131 citations

Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica.

1995 • 117 citations

Ordered cosmid library and high‐resolution physical—genetic map of Helicobacter pylori strain NCTC11638

1994 • 107 citations

Cloning and molecular characterization of a gene involved in Salmonella adherence and invasion of cultured epithelial cells

1993 • 106 citations

Pertussis toxin export requires accessory genes located downstream from the pertussis toxin operon

1993 • 104 citations

Intrinsic and extrinsic approaches for detecting genes in a bacterial genome

1994 • 103 citations

Molecular, functional, and evolutionary analysis of sequences specific to Salmonella.

1993 • 76 citations

Recombination between chromosomal IS200 elements supports frequent duplication formation in Salmonella typhimurium.

1995 • 75 citations

Adhesin regulatory genes within large, unstable DNA regions of pathogenic Escherichia coli: cross‐talk between different adhesin gene clusters

1994 • 74 citations

[19] Representational difference analysis in detection of genetic lesions in cancer

1995 • 69 citations

Helicobacter pylori and gastroduodenal disease: pathogenesis and host-parasite interaction.

1992 • 38 citations

Identification of a native Dichelobacter nodosus plasmid and implications for the evolution of the vap regions

1996 • 36 citations

A 20-minute ethidium bromide/high-salt extraction protocol for plasmid DNA.

1991 • 30 citations

Corrected Identity of Isolates of Helicobacter Pylori Reference Strain NCTC11637

1997 • 20 citations

A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene

1995 • 19 citations