Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice.

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.

1998 • 4,047 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

1998 • 659 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

1994 • 593 citations

Parental genomic imprinting of the human IGF2 gene

1993 • 422 citations

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

1994 • 391 citations

A community effect in animal development

1988 • 388 citations

Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

1997 • 349 citations

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

1997 • 327 citations

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

1998 • 290 citations

Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter

1990 • 277 citations

MCM proteins: evolution, properties, and role in DNA replication

1998 • 275 citations

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

1994 • 274 citations

Acromegaly and gastrointestinal cancer

1991 • 249 citations

Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.

1997 • 201 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

1995 • 188 citations

APC in the regulation of intestinal crypt fission

1998 • 168 citations

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

1997 • 153 citations

Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1

1997 • 151 citations

Involvement of IGF-II in human cancer

1996 • 148 citations

Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith- Wiedemann syndrome

1997 • 126 citations

Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice

1997 • 124 citations

Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis

1995 • 124 citations

Disproportionate growth in mice with Igf-2 transgenes.

1994 • 102 citations

The molecular and cellular biology of insulin-like growth factor II

1992 • 100 citations

HsMCM2/BM28: a novel proliferation marker for human tumors and normal tissues.

1998 • 87 citations

The Role of Insulin-Like Growth Factors in Small Intestinal Cell Growth and Development

1999 • 64 citations

Genetic Evaluation of Candidate Genes for the Mom1 Modifier of Intestinal Neoplasia in Mice

1996 • 63 citations

The Soluble Type 2 Insulin-like Growth Factor (IGF-II) Receptor Reduces Organ Size by IGF-II-mediated and IGF-II-independent Mechanisms

1998 • 60 citations

Variants at the secretory phospholipase A2 (PLA2G2A) locus: analysis of associations with familial adenomatous polyposis and sporadic colorectal tumours

1996 • 48 citations

Insulin-like growth factors and the multiplication of Tera-2, A human teratoma-derived cell line

1988 • 46 citations

High plasma insulin-like growth factor-II and low lipid content in transgenic mice: measurements of lipid metabolism

1994 • 45 citations

Association of rectal prolapse with colorectal cancer

1996 • 41 citations

An in situ hybridization histochemistry method for the use of alkaline phosphatase-labeled oligonucleotide probes in small intestine.

1991 • 40 citations

Reactivation of the maternally imprinted IGF2 allele in TGFα induced hepatocellular carcinomas in mice

1998 • 36 citations

Genomic imprinting and Igf2 influence liver tumorigenesis and loss of heterozygosity in SV40 T antigen transgenic mice.

1997 • 32 citations