Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor.

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin.

1988 • 843 citations

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

1989 • 645 citations

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1991 • 513 citations

Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity.

1989 • 445 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

1987 • 412 citations

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1989 • 406 citations

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei.

1981 • 350 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1988 • 314 citations

Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer.

1972 • 271 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Plant antitumor agents. 18. Synthesis and biological activity of camptothecin analogs

1980 • 232 citations

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

1988 • 213 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Treatment of malignant melanoma with camptothecin (NSC-100880).

1972 • 158 citations

High-performance liquid chromatographic analysis of the new antitumour drug SK&F 104864-A (NSC 609699) in plasma

1990 • 104 citations

Inhibition of spontaneous and experimental metastasis by a new derivative of camptothecin, CPT-11, in mice

1988 • 87 citations

Additional Members of the Rat Liver Lamin Polypeptide Family

1989 • 84 citations

Equilibrium kinetics of the new experimental anti-tumour compound SK&F 104864-A in aqueous solution

1990 • 76 citations

Plasma camptothecin (NSC-100880) levels during a 5-day course of treatment: relation to dose and toxicity.

1972 • 68 citations

Studies of topoisomerase-specific antitumor drugs in human lymphocytes using rabbit antisera against recombinant human topoisomerase II polypeptide.

1989 • 56 citations