The synovial expression and serum levels of interleukin‐6, interleukin‐11, leukemia inhibitory factor, and oncostatin m in rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee

1986 • 6,352 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Cytokine signal transduction

1994 • 1,358 citations

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1990 • 963 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Quantitative analysis of cytokine gene expression in rheumatoid arthritis.

1990 • 610 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Recombinant human interleukin‐6 (IL‐6/BSF‐2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

1988 • 458 citations

Interleukin-11: a new cytokine critical for osteoclast development.

1994 • 408 citations

Arthritis and Allied Conditions

1993 • 392 citations

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.

1992 • 373 citations

Interaction among hepatocyte-stimulating factors, interleukin 1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells.

1987 • 358 citations

Cytokine patterns of immunologically mediated tissue damage.

1992 • 285 citations

Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes.

1977 • 273 citations

Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor.

1989 • 272 citations

The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes

1988 • 263 citations

Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells.

1987 • 218 citations

Identification of alpha 2-macroglobulin as a carrier protein for IL-6.

1989 • 208 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

1993 • 206 citations

INTERLEUKIN-6 (IL-6) INDUCES THE PROLIFERATION OF SYNOVIAL FIBROBLASTIC CELLS IN THE PRESENCE OF SOLUBLE IL-6 RECEPTOR

1995 • 202 citations

Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.

1992 • 197 citations

Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum concentration of C-reactive protein and erythrocyte sedimentation rate.

1982 • 158 citations

Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

1988 • 156 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

RHEUMATOID ARTHRITIS: TREATMENT WHICH CONTROLS THE C-REACTIVE PROTEIN AND ERYTHROCYTE SEDIMENTATION RATE REDUCES RADIOLOGICAL PROGRESSION

1986 • 154 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 133 citations

High levels of “complexed” interleukin-6 in human blood.

1992 • 133 citations

The acute phase protein response in patients receiving subcutaneous IL-6

1995 • 129 citations

Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis.

1992 • 127 citations

Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases.

1993 • 124 citations

Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids.

1992 • 105 citations

IFN beta 2/BSF2/IL-6 is the monocyte-derived HSF that regulates receptor-specific acute phase gene regulation in hepatocytes.

1989 • 101 citations

IFNβ2/BSF2/IL‐6 Is the Monocyte‐derived HSF That Regulates Receptor‐specific Acute Phase Gene Regulation in Hepatocytes^a

1989 • 94 citations

Heterogeneous nature of the acute phase response. Differential regulation of human serum amyloid A, C-reactive protein, and other acute phase proteins by cytokines in Hep 3B cells.

1988 • 85 citations

Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production.

1992 • 83 citations

Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides

1993 • 72 citations

Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans

1992 • 63 citations

Production of serum amyloid A and C-reactive protein by HepG2 cells stimulated with combinations of cytokines or monocyte conditioned media: the effects of prednisolone

1992 • 62 citations

Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha.

1993 • 56 citations

The Validity of Surrogate Markers in Rheumatic Disease

1993 • 53 citations

Interleukin-11 promotes accessory cell-dependent B-cell differentiation in humans

1992 • 52 citations

The Relation of Radiographic Changes to Serum Acute-phase Proteins and Rheumatoid Factor in 200 Patients with Rheumatoid Arthritis

1988 • 50 citations

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts

1991 • 42 citations

High circulating leukaemia inhibitory factor (LIF) in patients with giant cell arteritis: independent regulation of LIF and IL-6 under corticosteroid therapy

1993 • 42 citations

Circulating levels of IL-11 and leukaemia inhibitory factor (LIF) do not significantly participate in the production of acute-phase proteins by the liver

1996 • 24 citations

Dr de Vries' letter was shown to Dr Emery and colleagues who reply:

1993 • 9 citations

Allergic Reactions in Vaccinia-Immune Rabbits

1930 • 2 citations