Inhibition of the SHV-1 β-Lactamase by Sulfones: Crystallographic Observation of Two Reaction Intermediates with Tazobactam^,

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Catalytic properties of class A β-lactamases: efficiency and diversity

1998 • 346 citations

Inhibitor-resistant TEM -lactamases: phenotypic, genetic and biochemical characteristics

1999 • 254 citations

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

1985 • 223 citations

Inactivation of class A .beta.-lactamases by clavulanic acid: the role of arginine-244 in a proposed nonconcerted sequence of events

1993 • 135 citations

The catalytic mechanism of beta-lactamases: NMR titration of an active-site lysine residue of the TEM-1 enzyme.

1996 • 117 citations

Nomenclature of TEM beta-lactamases

1997 • 106 citations

Resolving the Antibiotic Paradox

1998 • 66 citations

X-ray Structure of the Asn276Asp Variant of the Escherichia coli TEM-1 β-Lactamase: Direct Observation of Electrostatic Modulation in Resistance to Inactivation by Clavulanic Acid^,

1999 • 48 citations

Modeling Study on a Hydrolytic Mechanism of Class A β-Lactamases

1996 • 45 citations

Structural studies on tazobactam

1991 • 14 citations