Coordinated Maturational Regulation of PHEX and Renal Phosphate Transport Inhibitory Activity: Evidence for the Pathophysiological Role of PHEX in X-Linked Hypophosphatemia

Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

1990 • 1,546 citations

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

1995 • 1,077 citations

Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development

1992 • 949 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Disorders of Bone and Mineral Metabolism

1992 • 713 citations

Transgenic Animals

1988 • 473 citations

RICKETS RESISTANT TO VITAMIN D THERAPY

1937 • 453 citations

Developmental expression of bone sialoprotein mRNA in rat mineralized connective tissues

1992 • 393 citations

Cellular expression of bone‐related proteins during in vitro osteogenesis in rat bone marrow stromal cell cultures

1994 • 368 citations

Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture.

1983 • 363 citations

Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*

1991 • 352 citations

Tissue specificity and developmental expression of rat osteopontin

1987 • 317 citations

Inhibition of Renal Phosphate Transport by a Tumor Product in a Patient with Oncogenic Osteomalacia

1994 • 311 citations

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

1997 • 283 citations

Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.

1992 • 219 citations

Molecular cloning and primary structure of Kell blood group protein.

1991 • 218 citations

Protection against lipoapoptosis of β cells through leptin-dependent maintenance of Bcl-2 expression

1998 • 211 citations

Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice

1989 • 207 citations

Temporal changes in matrix protein synthesis and mRNA expression during mineralized tissue formation by adult rat bone marrow cells in culture

1994 • 197 citations

cDNA Cloning of the MurinePexGene Implicated in X-Linked Hypophosphatemia and Evidence for Expression in Bone

1996 • 174 citations

Bone matrix mRNA expression in differentiating fetal bovine osteoblasts

1992 • 141 citations

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.

1989 • 130 citations

The renal phosphate transport defect in normal mice parabiosed to X-linked hypophosphatemic mice persists after parathyroidectomy

1989 • 125 citations

The migration of osteoblasts

1977 • 111 citations

Cloning and Sequencing of Human PEX from a Bone cDNA Library: Evidence for Its Developmental Stage-Specific Regulation in Osteoblasts

1997 • 109 citations

Serum 1,25-dihydroxyvitamin D levels in subjects with X-linked hypophosphatemic rickets and osteomalacia

1982 • 83 citations

Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse

1996 • 75 citations

Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the hypophosphatemic mouse. Evidence for a generalized defect of vitamin D metabolism.

1986 • 71 citations

Renal Na+-phosphate cotransporter gene expression in X-linked Hyp and Gy mice

1996 • 70 citations

Phosphatonin - a new phosphaturetic hormone? (Lessons from tumour-induced osteomalacia and X-linked hypophosphataemia)

1997 • 66 citations

Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp Mice: Evidence That the HYP gene locus product is an extrarenal factor

1995 • 53 citations

Temporal Changes of mRNA Expression of Matrix Proteins and Parathyroid Hormone and Parathyroid Hormone–Related Protein (PTH/PTHrP) Receptor in Bone Development

1997 • 48 citations