Osteomalacia in Hyp Mice Is Associated with Abnormal Phex Expression and with Altered Bone Matrix Protein Expression and Deposition¹

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Increased bone formation in osteocalcin-deficient mice

1996 • 1,692 citations

Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats

1988 • 1,330 citations

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

1995 • 1,077 citations

Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues.

1990 • 657 citations

Isolation and Characterization of MC3T3-E1 Preosteoblast Subclones with Distinct In Vitro and In Vivo Differentiation/Mineralization Potential

1999 • 641 citations

Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1

1999 • 514 citations

Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins

1995 • 452 citations

Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin

1998 • 438 citations

Expression of bone sialoprotein (BSP) in developing human tissues

1991 • 407 citations

Osteogenic Stem Cells and the Stromal System of Bone and Marrow

1989 • 394 citations

Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice.

1997 • 283 citations

Human bone sialoprotein. Deduced protein sequence and chromosomal localization.

1990 • 275 citations

Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome

1994 • 259 citations

Localization of bone sialoprotein (BSP) expression to sites of mineralized tissue formation in fetal rat tissues by In Situ hybridization

1991 • 240 citations

Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.

1992 • 219 citations

Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice

1989 • 207 citations

Pex Gene Deletions in Gy and Hyp Mice Provide Mouse Models for X-Linked Hypophosphatemia

1997 • 198 citations

cDNA Cloning of the MurinePexGene Implicated in X-Linked Hypophosphatemia and Evidence for Expression in Bone

1996 • 174 citations

Pex mRNA Is Localized in Developing Mouse Osteoblasts and Odontoblasts

1998 • 159 citations

Effects of Bone CS-Proteoglycans, DS-Decorin, and DS-Biglycan on Hydroxyapatite Formation in a Gelatin Gel

1997 • 153 citations

Molecular basis of renal disease. X-linked hypophosphataemia: a homologous disorder in humans and mice

1999 • 142 citations

Cloning of Human PEXcDNA

1998 • 135 citations

Bone sialoprotein in developing porcine dental tissues: Cellular expression and comparison of tissue localization with osteopontin and osteonectin

1993 • 127 citations

Intrinsic mineralization defect inHyp mouse osteoblasts

1998 • 116 citations

Cloning and Sequencing of Human PEX from a Bone cDNA Library: Evidence for Its Developmental Stage-Specific Regulation in Osteoblasts

1997 • 109 citations

Regulation of bone sialoprotein mRNA by steroid hormones.

1989 • 105 citations

Defective bone formation by hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect

1992 • 104 citations

Defective Bone Formation by Transplanted Hyp Mouse Bone Cells into Normal Mice*

1988 • 88 citations

Elucidating the functions of bone sialoprotein and osteopontin in bone formation.

1992 • 68 citations

Phosphatonin - a new phosphaturetic hormone? (Lessons from tumour-induced osteomalacia and X-linked hypophosphataemia)

1997 • 66 citations

Coordinated Maturational Regulation of PHEX and Renal Phosphate Transport Inhibitory Activity: Evidence for the Pathophysiological Role of PHEX in X-Linked Hypophosphatemia

1999 • 54 citations

Positional cloning of the PEX gene: new insights into the pathophysiology of X-linked hypophosphatemic rickets

1997 • 42 citations

Effect of 1,25-dihydroxyvitamin D3 treatment on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice

1995 • 37 citations

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia

1999 • 24 citations

Osteocalcin abnormalities in Hyp mice reflect altered genetic expression and are not due to altered clearance, affinity for mineral, or ambient phosphorus levels.

1996 • 16 citations