Pex Gene Deletions in Gy and Hyp Mice Provide Mouse Models for X-Linked Hypophosphatemia

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets

1995 • 1,077 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

A new bacteriophage P1–derived vector for the propagation of large human DNA fragments

1994 • 857 citations

[13] Evolutionary families of metallopeptidases

1995 • 794 citations

Families of zinc metalloproteases

1994 • 769 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum

1995 • 496 citations

Hypophosphatemia: mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets.

1976 • 399 citations

Expression cloning of human and rat renal cortex Na/Pi cotransport.

1993 • 355 citations

Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex.

1991 • 257 citations

Molecular cloning and primary structure of Kell blood group protein.

1991 • 218 citations

Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)

1994 • 200 citations

cDNA Cloning of the MurinePexGene Implicated in X-Linked Hypophosphatemia and Evidence for Expression in Bone

1996 • 174 citations

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions.

1989 • 130 citations

The Gy mutation: another cause of X-linked hypophosphatemia in mouse.

1986 • 127 citations

Renal Na(+)-phosphate cotransport in murine X-linked hypophosphatemic rickets. Molecular characterization.

1994 • 114 citations

Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse.

1983 • 111 citations

Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11

1996 • 94 citations

Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11

1991 • 79 citations

[47] Using bacteriophage P1 system to clone high molecular weight genomic DNA

1992 • 75 citations

Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the hypophosphatemic mouse. Evidence for a generalized defect of vitamin D metabolism.

1986 • 71 citations

Kinetic evidence that His‐711 of neutral endopeptidase 24.11 is involved in stabilization of the transition state

1993 • 45 citations

Audiometric evidence for two forms of X‐linked hypophosphatemia in humans, apparent counterparts of Hyp and Gy mutations in mouse

1987 • 42 citations

Asp650 is crucial for catalytic activity of neutral endopeptidase 24‐11

1994 • 42 citations

Murine common acute lymphoblastic leukemia antigen (CD10 neutral endopeptidase 24.11). Molecular characterization, chromosomal localization, and modeling of the active site.

1992 • 42 citations

A novel locus for non-syndromic sensorineural deafness (DFN6) maps to chromosome Xp22

1996 • 42 citations

Investigation of the Mechanism for Abnormal Renal 25 Hydroxyvitamin D₃-1-Hydroxylase Activity in the XLinkedHypMouse*

1984 • 31 citations

Femoral abnormalities and vitamin D metabolism in X‐linked hypophosphatemic (Hyp and Gy) mice

1995 • 29 citations

Renal expression of Na+-phosphate cotransporter mRNA and protein: Effect of the Gy mutation and low phosphate diet

1996 • 24 citations

Effects of altered diet on serum levels of 1,25-dihydroxyvitamin D and parathyroid hormone in X-linked hypophosphatemic (Hyp and Gy) mice

1996 • 19 citations

The molecular defect in the renal sodium‐phosphate transporter expression pathway of Gyro (Gy) mice is distinct from that of hypophosphatemie (Hyp) mice

1996 • 16 citations

Variable Phosphate-Mediated Regulation of Vitamin D Metabolism in the Murine Hypophosphatemic Rachitic/Osteomalacic Disorders*

1991 • 11 citations