Novel Protein Domains and Repeats in Drosophila melanogaster: Insights into Structure, Function, and Evolution

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1994 • 63,397 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Pfam protein families database.

2002 • 14,298 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

Predicting Coiled Coils from Protein Sequences

1991 • 3,977 citations

Prediction of Protein Secondary Structure at Better than 70% Accuracy

1993 • 2,958 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Evidence for a clade of nematodes, arthropods and other moulting animals

1997 • 1,581 citations

Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes.

1990 • 1,542 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

SMART: a web-based tool for the study of genetically mobile domains

2000 • 1,298 citations

The Pfam Protein Families Database

2000 • 1,235 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

SCOP: a Structural Classification of Proteins database

1997 • 945 citations

A Systematic Analysis of Human Disease-Associated Gene Sequences In Drosophila melanogaster

2001 • 903 citations

Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy

1998 • 882 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

Statistics of local complexity in amino acid sequences and sequence databases

1993 • 735 citations

A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities

1998 • 731 citations

A Striking Organization of a Large Family of Human Neural Cadherin-like Cell Adhesion Genes

1999 • 716 citations

A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B

1998 • 660 citations

Multiple protein sequence alignment from tertiary structure comparison: Assignment of global and residue confidence levels

1992 • 655 citations

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

1991 • 635 citations

A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis

1998 • 621 citations

Protein Repeats: Structures, Functions, and Evolution

2001 • 607 citations

SCOP: a Structural Classification of Proteins database

2000 • 564 citations

THE MULTIPLICITY OF DOMAINS IN PROTEINS

1995 • 512 citations

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

2001 • 504 citations

A census of protein repeats

1999 • 413 citations

Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.

1986 • 411 citations

Positional cloning of the gene for X-linked retinitis pigmentosa 2

1998 • 371 citations

The clip-domain family of serine proteinases in arthropods

2000 • 370 citations

Eukaryotic Signalling Domain Homologues in Archaea and Bacteria. Ancient Ancestry and Horizontal Gene Transfer

1999 • 328 citations

Structural Evidence for Evolution of the β/α Barrel Scaffold by Gene Duplication and Fusion

2000 • 301 citations

Pathway Leading to Correctly Folded β-Tubulin

1996 • 272 citations

HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions

2000 • 271 citations

Ubiquitin-specific proteases of Saccharomyces cerevisiae. Cloning of UBP2 and UBP3, and functional analysis of the UBP gene family

1992 • 250 citations

Solution structure of a DNA-binding unit of Myb: a helix-turn-helix-related motif with conserved tryptophans forming a hydrophobic core.

1992 • 241 citations

PER and TIM Inhibit the DNA Binding Activity of a Drosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription

1999 • 239 citations

Evidence for PDZ domains in bacteria, yeast, and plants

1997 • 237 citations

Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses

1999 • 231 citations

The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation

2001 • 222 citations

Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin

2000 • 216 citations

CHROMA: consensus-based colouring of multiple alignments for publication

2001 • 207 citations

SPRY domains in ryanodine receptors (Ca2+-release channels)

1997 • 201 citations

A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor α gene expression: Molecular cloning, sequencing, characterization, and chromosomal assignment

1999 • 197 citations

Human deltex is a conserved regulator of Notch signalling

1998 • 189 citations

SCOP: a Structural Classification of Proteins database

1999 • 183 citations

Congenital disorders of glycosylation: genetic model systems lead the way

2001 • 168 citations

A Link between Blood Coagulation and Prophenol Oxidase Activation in Arthropod Host Defense

2000 • 163 citations

Properties of the prophenoloxidase activating enzyme of the freshwater crayfish, Pacifastacus leniusculus

2001 • 162 citations

CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex.

1991 • 155 citations

SEALS: a system for easy analysis of lots of sequences.

1997 • 144 citations

Severity of phenotype in cystinosis varies with mutations in the CTNS gene: predicted effect on the model of cystinosin

1999 • 143 citations

The Targeting of Cystinosin to the Lysosomal Membrane Requires a Tyrosine-based Signal and a Novel Sorting Motif

2001 • 134 citations

Mutations in the Novel Membrane Protein Spinster Interfere with Programmed Cell Death and Cause Neural Degeneration inDrosophila melanogaster

2001 • 133 citations

Molecular mechanism of hemolymph clotting system in Limulus

1992 • 133 citations

Molecular characterization of the oafA locus responsible for acetylation of Salmonella typhimurium O-antigen: oafA is a member of a family of integral membrane trans-acylases

1996 • 123 citations

deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster.

1990 • 123 citations

Accurate formula for P-values of gapped local sequence and profile alignments

2000 • 120 citations

Structure and Evolution of Parallel β-Helix Proteins

1998 • 120 citations

Molecular cloning of an insect pheromone‐binding protein

1989 • 113 citations

Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all β-trefoil proteins 1 1Edited by J. Thornton

2000 • 113 citations

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.

1991 • 112 citations

Fluoxetine-Resistant Mutants in C. elegans Define a Novel Family of Transmembrane Proteins

1999 • 107 citations

New mutations in MID1 provide support for loss of function as the cause of X-linked Opitz syndrome

2000 • 107 citations

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

2000 • 106 citations

Crystal structure of a class I α1,2-mannosidase involved in N-glycan processing and endoplasmic reticulum quality control

2000 • 100 citations

The solution structure of VAT-N reveals a ‘missing link’ in the evolution of complex enzymes from a simple βαββ element

1999 • 93 citations

A Polypeptide with Similarity to Phycocyanin α-Subunit Phycocyanobilin Lyase Involved in Degradation of Phycobilisomes

1999 • 92 citations

Identification and analysis of the dissimilatory nitrous oxide reduction genes, nosRZDFY, of Rhizobium meliloti

1996 • 78 citations

Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor.

1996 • 77 citations

Homologues of archaeal rhodopsins in plants, animals and fungi: structural and functional predications for a putative fungal chaperone protein

2001 • 75 citations

Approximate Statistics of Gapped Alignments

1999 • 72 citations

Domains in proteins: Definitions, location, and structural principles

1985 • 67 citations

Crystal structure of N-acyl-d-glucosamine 2-epimerase from porcine kidney at 2.0 Å resolution

2000 • 62 citations

Two Separate Functions Are Encoded by the Carboxyl-terminal Domains of the Yeast Cyclase-associated Protein and Its Mammalian Homologs

1996 • 61 citations

Expression Cloning of a Novel Suppressor of the Lec15 and Lec35 Glycosylation Mutations of Chinese Hamster Ovary Cells

1996 • 59 citations

Cloning and sequencing of a cDNA for the hemolymph juvenile hormone binding protein of larval Manduca sexta.

1990 • 54 citations

Adf-1 Is a Nonmodular Transcription Factor That Contains a TAF-Binding Myb-Like Motif

1998 • 47 citations

The A Modules of the Azotobacter vinelandii Mannuronan-C-5-Epimerase AlgE1 Are Sufficient for both Epimerization and Binding of Ca ²⁺

1999 • 45 citations

Function of Tubulin Binding Proteins in Vivo

2000 • 37 citations

Cloning and Characterization of Physarum polycephalumTectonins

1998 • 36 citations

Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease

1999 • 34 citations

Were protein internal repeats formed by ‘bricolage’?

2001 • 28 citations

Limits of homology detection by pairwise sequence comparison

2001 • 24 citations

Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search

2000 • 11 citations