Comparison of interleukin 2 and 12‐O‐tetradecanoyl‐phorbol 13‐acetate as signals for protein kinase C activation in purified human T lymphocytes

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Transient expression of interleukin 2 receptors. Consequences for T cell growth.

1983 • 613 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells.

1981 • 350 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene

1987 • 303 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

T‐Lymphocyte Activation: The Role of Protein Kinase C and the Bifurcating Inositol Phospholipid Signal Transduction Pathway

1987 • 203 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.

1987 • 153 citations

Association of protein kinase C activation with IL 2 receptor expression.

1986 • 146 citations

Signal transduction and intracellular events in T-lymphocyte activation

1986 • 134 citations

Cloning of rat brain protein kinase C complementary DNA

1986 • 124 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

IL 2 receptor induction on human T lymphocytes: role for IL 2 and monocytes.

1985 • 100 citations

Transmembrane signalling by the T3-antigen receptor complex

1985 • 82 citations

A new possible regulatory system for protein phosphorylation in human peripheral lymphocytes. I. Characterization of a calcium-activated, phospholipid-dependent protein kinase.

1981 • 82 citations

Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes.

1987 • 67 citations

Phosphorylation of calf thymus H1 histone by calcium-activated, phospholipid-dependent protein kinase

1980 • 66 citations

Rapid down‐regulation of protein kinase C and membrane association in phorbol ester‐treated leukemia cells

1985 • 34 citations

Proliferation of T lymphocytes in response to interleukin 2 varies with their state of activation.

1986 • 33 citations

Phytohemagglutinin treatment of T lymphocytes stimulates rapid increases in activity of both particulate and cytosolic protein kinase C

1986 • 32 citations

CD2 and CD3 antigens mobilize Ca²⁺ independently

1986 • 31 citations

Accessory function and interleukin 1 production by human leukemic cell lines.

1984 • 30 citations

Phorbol ester-induced alteration of protein kinase C catalytic properties occurs at the membrane level and is not reproduced by physiological stimuli

1986 • 30 citations

Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?

1988 • 19 citations

Interleukin-2 stimulus-response coupling is calcium independent.

1987 • 12 citations