Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC ^−/− Colon Carcinoma

1997 • 3,234 citations

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 • 1,984 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

Gene silencing in mammals by small interfering RNAs

2002 • 1,403 citations

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

2002 • 1,117 citations

β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

2002 • 1,076 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Effective expression of small interfering RNA in human cells

2002 • 827 citations

U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells

2002 • 715 citations

RNA interference—2001

2001 • 698 citations

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- ras

1993 • 627 citations

Gene silencing using micro-RNA designed hairpins

2002 • 310 citations

Mammalian RNAi for the masses

2002 • 284 citations

Tetracycline Repressor, tetR, rather than the tetR–Mammalian Cell Transcription Factor Fusion Derivatives, Regulates Inducible Gene Expression in Mammalian Cells

1998 • 250 citations

RNA interference: the new somatic cell genetics?

2002 • 218 citations

Monitoring global messenger RNA changes in externally controlled microarray experiments

2003 • 177 citations

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

2001 • 151 citations

An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene

2001 • 147 citations

Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation

2002 • 124 citations

Control of the Functional Activity of an Antisense RNA by a Tetracycline-Responsive Derivative of the Human U6 snRNA Promoter

2000 • 82 citations

Proof-of-principle: oncogenic beta-catenin is a valid molecular target for the development of pharmacological inhibitors.

2002 • 69 citations

Target disruption of the mutant β-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype

2002 • 44 citations

Genetics services and market forces

2002 • 2 citations