A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

The MAPK signaling cascade

1995 • 3,300 citations

Histopathology of the skin

1975 • 2,630 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1999 • 970 citations

MAP kinase pathways

1999 • 875 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry

1999 • 602 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

From receptors to stress-activated MAP kinases

1999 • 525 citations

Keratinocyte-specific transglutaminase of cultured human epidermal cells: Relation to cross-linked envelope formation and terminal differentiation

1985 • 479 citations

Inflammatory Skin Diseases, T Cells, and Immune Surveillance

1999 • 474 citations

Epidermal stem cells: markers, patterning and the control of stem cell fate

1998 • 398 citations

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

1998 • 392 citations

Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

1997 • 351 citations

c-Myc promotes differentiation of human epidermal stem cells

1997 • 318 citations

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

1995 • 303 citations

Growth factor activation of MAP kinase requires cell adhesion

1997 • 301 citations

Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro

1999 • 246 citations

Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts

2000 • 229 citations

Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins

1998 • 211 citations

Interleukin-1 and Cutaneous Inflammation: A Crucial Link Between Innate and Acquired Immunity

2000 • 204 citations

Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis.

1995 • 194 citations

Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases

1997 • 192 citations

The Epidermis: Genes On – Genes Off

1997 • 181 citations

The Interleukin-1 Axis and Cutaneous Inflammation

1995 • 163 citations

β1 Integrins Regulate Keratinocyte Adhesion and Differentiation by Distinct Mechanisms

2000 • 147 citations

Mechanical deformation promotes secretion of IL-1 alpha and IL-1 receptor antagonist.

1997 • 122 citations

It's Got You Covered

2000 • 119 citations

IL-12, independently of IFN-gamma, plays a crucial role in the pathogenesis of a murine psoriasis-like skin disorder.

1999 • 119 citations

IL-12, Independently of IFN-γ, Plays a Crucial Role in the Pathogenesis of a Murine Psoriasis-Like Skin Disorder

1999 • 105 citations

Epidermal differentiation

1990 • 101 citations

The Roles of Keratinocyte-Derived Cytokines in the Epidermis and Their Possible Responses to UVA-Irradiation

1999 • 101 citations

Engagement of CD11b and CD11c β2 integrin by antibodies or soluble CD23 induces IL-1β production on primary human monocytes through mitogen-activated protein kinase–dependent pathways

2000 • 94 citations

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1

1996 • 94 citations

Defining the Regulatory Factors Required for Epidermal Gene Expression

2000 • 84 citations

Constitutively Active Mutant of the Mitogen-activated Protein Kinase Kinase MEK1 Induces Epithelial Dedifferentiation and Growth Inhibition in Madin-Darby Canine Kidney-C7 Cells

1997 • 73 citations

Differential Expression of Human Cornifin α and β in Squamous Differentiating Epithelial Tissues and Several Skin Lesions.

1997 • 66 citations

A Novel Component of Epidermal Cell–Matrix and Cell–Cell Contacts: Transmembrane Protein Type XIII Collagen

1999 • 65 citations

The Interleukin-1 Axis and Cutaneous Inflammation.

1995 • 64 citations

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.

2001 • 58 citations

Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture

1997 • 55 citations

Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

1999 • 55 citations

Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo.

1991 • 44 citations

Epidermal remodelling in psoriasis

1996 • 42 citations