[44] Transmembrane Ca2+ signaling and a new class of inhibitors

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Ca2+-induced hydrophobic site on calmodulin: Application for purification of calmodulin by phenyl-Sepharose affinity chromatography

1982 • 877 citations

Cyclic 3′,5′-nucleotide phosphodiesterase

1970 • 824 citations

Calmodulin

1982 • 771 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.

1982 • 516 citations

Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain

1970 • 491 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

Hydrophobic regions function in calmodulin-enzyme(s) interactions.

1980 • 363 citations

Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980 • 335 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

R 24571: A new powerful inhibitor of red blood cell Ca++-transport ATPase and of calmodulin-regulated functions

1981 • 260 citations

Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

1984 • 249 citations

Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction.

1979 • 201 citations

Ca2+-dependent high-affinity complex formation between calmodulin and melittin

1983 • 191 citations

Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase. The effect on actin-activated MgATPase activity.

1983 • 174 citations

A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.

1978 • 171 citations

Activity-structure relationship of calmodulin antagonists, Naphthalenesulfonamide derivatives.

1981 • 163 citations

Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives.

1982 • 156 citations

High affinity binding of the mastoparans by calmodulin

1983 • 154 citations

Calmodulin Antagonists and Cellular Physiology

1985 • 144 citations

Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation.

1984 • 143 citations

Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle

1984 • 138 citations

Calcium-dependent affinity chromatography of S-100 and calmodulin on calmodulin antagonist-coupled Sepharose.

1981 • 131 citations

Phosphorylation of smooth muscle myosin light chain kinase by Ca2+-activated, phospholipid-dependent protein kinase.

1985 • 128 citations

N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases.

1985 • 122 citations

Hydrophobic interaction of the Ca2+-calmodulin complex with calmodulin antagonists. Naphthalenesulfonamide derivatives.

1982 • 113 citations

Interaction of local anesthetics with calmodulin

1981 • 96 citations

Ca2+-phospholipid dependent phosphorylation of smooth muscle myosin

1982 • 85 citations

Activation of myosin light chain kinase by trypsin

1980 • 84 citations

Intracellular calcium

1984 • 74 citations

Calmodulin and intracellular Ca2+ receptors

1983 • 58 citations

Calcium ion-dependent covalent modification of calmodulin with norchlorpromazine isothiocyanate

1983 • 58 citations

Inhibition of phorbol ester-induced phenotypic differentiation of HL-60 cells by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, a protein kinase inhibitor.

1986 • 56 citations

Effects on calmodulin of bepridil, an antianginal agent.

1984 • 55 citations

N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C

1986 • 53 citations

Allosteric interactions among drug binding sites on calmodulin

1983 • 44 citations

CAPP‐calmodulin: A potent competitive inhibitor of calmodulin actions

1984 • 43 citations

Two Types of Calmodulin Antagonists: A Structurally Related Interaction

1984 • 31 citations

Possible involvement of phosphorylation of a 36,000-dalton protein of rat basophilic leukemia (RBL-2H3) cell membranes in serotonin release

1986 • 28 citations

The binding of the calcium channel blocker, bepridil, to calmodulin

1986 • 27 citations

Modulation of calmodulin function and of Ca2+-induced smooth muscle contraction by the calmodulin antagonist, HT-74.

1986 • 25 citations

Calcium-dependent hydrophobic chromatography of calmodulin, S-100 protein and troponin-C

1984 • 24 citations

Inhibitory action of phorbol myristate acetate on histamine secretion and polyphosphoinositide turnover induced by compound 4880 in mast cells

1985 • 19 citations

Inhibitors of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced multinucleated cell formation and HTLV‐I p19 antigen expression in HTLV‐I‐infected T‐cell line KH‐2Lo

1986 • 19 citations

Calcium-independent activation of calcium ion dependent cyclic nucleotide phosphodiesterase by synthetic compounds: quinazolinesulfonamide derivatives

1983 • 15 citations

Calcium-dependent interactions with calmodulin of a fluorescent calmodulin antagonist: N2-dansyl-l-arginine-4-t-butylpiperidine amide

1983 • 10 citations

Concanavalin A- and calcium-dependent phosphorylation of a protein of 80 kDa in mouse lymphocytes rendered permeable to exogenously added [γ-32P]ATP

1986 • 10 citations