Somatic hypermutation of Ig genes in patients with xeroderma pigmentosum (XP-D)

By-passing immunization

1991 • 1,603 citations

DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 • 795 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.

1990 • 552 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.

1994 • 381 citations

Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

1993 • 332 citations

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

1990 • 318 citations

Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair

1993 • 317 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Somatic hypermutation

1995 • 248 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

The maturation of the immune response

1993 • 219 citations

Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.

1980 • 199 citations

It was a very good year for DNA repair

1994 • 181 citations

National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA.

1975 • 170 citations

Human IgM⁺IgD⁺ B cells, the major B cell subset in the peripheral blood, express Vϰ genes with no or little somatic mutation throughout life

1993 • 166 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy

1994 • 134 citations

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3′ of C kappa and occurs on passenger transgenes.

1991 • 132 citations

Distribution of Mutations around Rearranged Heavy-Chain Antibody Variable-Region Genes

1990 • 129 citations

Somatic hypermutation: How many mechanisms diversify V region sequences?

1995 • 116 citations

Distribution of mutations around rearranged heavy-chain antibody variable-region genes.

1990 • 93 citations

The 5′ boundary of somatic hypermutation in a Vχ gene is in the leader intron

1994 • 86 citations

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

1991 • 82 citations

Xeroderma pigmentosum, Cockayne's syndrome, helicases, and DNA repair: What's the relationship?

1992 • 81 citations

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

1994 • 69 citations

Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes

1994 • 69 citations

Maturation of the immune response

1994 • 10 citations