Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

2006 • 6,720 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

2001 • 2,503 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Plasticity of CD4+ T Cell Lineage Differentiation

2009 • 1,476 citations

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

2007 • 1,443 citations

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2009 • 1,274 citations

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

2009 • 1,098 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor Eomesodermin

2003 • 956 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

IL-21 and TGF-β are required for differentiation of human TH17 cells

2008 • 882 citations

TGF-β: A Master of All T Cell Trades

2008 • 805 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

2007 • 770 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

Preferential Generation of Follicular B Helper T Cells from Foxp3 ⁺ T Cells in Gut Peyer's Patches

2009 • 559 citations

Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

2005 • 525 citations

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

2008 • 520 citations

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

2009 • 495 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

2008 • 418 citations

Hematopoiesis Controlled by Distinct TIF1γ and Smad4 Branches of the TGFβ Pathway

2006 • 365 citations

Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice

2006 • 341 citations

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

2006 • 314 citations

Mice Lacking Smad3 Are Protected Against Cutaneous Injury Induced by Ionizing Radiation

2002 • 281 citations

Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells

2001 • 270 citations

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

2006 • 217 citations

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads

2008 • 181 citations

Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment

2007 • 177 citations

The effect of TGF-β1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells

2000 • 154 citations

Coordinate regulation of cell growth and differentiation by TGF-β superfamily and Runx proteins

2004 • 152 citations

IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation

2008 • 150 citations

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor

2008 • 144 citations

Cyclic Adenosine Monophosphate Suppresses the Transcription of Proinflammatory Cytokines via the Phosphorylated c-Fos Protein

2009 • 136 citations

Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells

2008 • 121 citations

Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells

2007 • 107 citations

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile

2005 • 107 citations

Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis

2008 • 91 citations

A unique subpopulation of CD4⁺ regulatory T cells controls wasting disease, IL‐10 secretion and T cell homeostasis

2003 • 89 citations

OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells

2008 • 85 citations

Characterization of theMADH2/Smad2Gene, a HumanMadHomolog Responsible for the Transforming Growth Factor-β and Activin Signal Transduction Pathway

1998 • 52 citations

IL-2 Regulates CD103 Expression on CD4+ T Cells in Scurfy Mice that Display Both CD103-Dependent and Independent Inflammation

2009 • 23 citations

Increase of CD4⁺CD25⁺T cells in Smad3^-/-mice

2006 • 6 citations