Astrocytes Express Elements of the Class II Endocytic Pathway and Process Central Nervous System Autoantigen for Presentation to Encephalitogenic T Cells

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

Astrocyte heterogeneity

1990 • 254 citations

On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation

1985 • 241 citations

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation.

1996 • 230 citations

Antigen conformation determines processing requirements for T-cell activation.

1984 • 181 citations

Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

1986 • 178 citations

Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.

1996 • 174 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

1987 • 163 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

Identification of distinct regions of 5' flanking DNA that mediate constitutive, IFN-gamma, STAT1, and TGF-beta-regulated expression of the class II transactivator gene.

1998 • 156 citations

IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.

1997 • 153 citations

Immortalization of Neural Cells Via Retrovirus-Mediated Oncogene Transduction

1989 • 151 citations

Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

1987 • 147 citations

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 • 147 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5

1997 • 140 citations

Identification of Distinct Regions of 5′ Flanking DNA That Mediate Constitutive, IFN-γ, STAT1, and TGF-β-Regulated Expression of the Class II Transactivator Gene

1998 • 131 citations

Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes.

1998 • 116 citations

Distinct antigen MHC class II complexes generated by separate processing pathways.

1996 • 115 citations

Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.

1991 • 107 citations

Human astrocytes are only partially competent antigen presenting cells

1994 • 106 citations

Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-γ-Activated SJL/J Astrocytes

1998 • 91 citations

AN IN VITRO SYSTEM FOR THE STUDY OF MYELIN SYNTHESIS¹

1969 • 91 citations

Multiple sclerosis Immunomodulatory effects of human astrocytes on T cells

1994 • 88 citations

Ia expression in chronic relapsing experimental allergic encephalomyelitis induced by long-term cultured T cell lines in mice.

1986 • 78 citations

Induction of primary T cell responses by human glial cells

1993 • 77 citations

Recombinant Retroviruses Encoding Simian Virus 40 Large T Antigen and Polyomavirus Large and Middle T Antigens

1986 • 70 citations

The H-2KbtsA58 transgenic mouse: A new tool for the rapid generation of novel cell lines

1995 • 65 citations

Is there a ?dopaminergic glial cell??

1984 • 60 citations

Immortalization of immature and mature mouse astrocytes with SV40 T antigen

1994 • 44 citations

The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain.

1996 • 44 citations

A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.

1991 • 42 citations

Induction of antigen presentation ability in purified cultures of astroglia by interferon-gamma.

1986 • 42 citations

A novel antigen-processing-defective phenotype in major histocompatibility complex class II-positive CIITA transfectants is corrected by interferon-gamma.

1995 • 35 citations

An Isotype-specific Activator of Major Histocompatibility Complex (MHC) Class II Genes That Is Independent of Class II Transactivator

1997 • 35 citations

Detailed analysis of early immunopathologic events during lesion formation in acute experimental autoimmune encephalomyelitis

1989 • 32 citations

Effect of removal of glutamine and addition of dexamethasone on the activities of glutamine synthetase, ornithine decarboxylase and lactate dehydrogenase in primary cultures of forebrain and cerebellar astrocytes

1986 • 20 citations

Mouse class II transactivator: cDNA sequence and amino acid comparison with the human class II transactivator

1997 • 19 citations

Immortalization and characterization of rat microglial cells

1995 • 15 citations

Destruction of proteins as a creative force

1997 • 13 citations

Intercellular interactions in myelin-specific autoimmunity

1988 • 10 citations

Highly efficient peptide binding and T cell activation by MHC class II molecules of CIITA-transfected cells

1996 • 9 citations