Alterations in the early steps of the insulin-signaling system in skeletal muscle of GH-transgenic mice

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Effect of Growth Hormone on Carbohydrate and Lipid Metabolism

1987 • 584 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

1982 • 434 citations

Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

1993 • 348 citations

The Effect of Growth Hormone on Glucose Metabolism and Insulin Secretion in Man*

1982 • 331 citations

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

1992 • 328 citations

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting

1997 • 280 citations

Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action

1986 • 232 citations

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

1993 • 220 citations

Growth Hormone and Prolactin Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrate-1, -2, and -3, Their Association with p85 Phosphatidylinositol 3-Kinase (PI3-kinase), and Concomitantly PI3-kinase Activation via JAK2 Kinase

1998 • 182 citations

Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats.

1996 • 141 citations

Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary Adipocytes

1995 • 134 citations

The Insulin Resistance of Acromegaly: Evidence for Two Alterations in the Insulin Receptor on Circulating Monocytes

1979 • 132 citations

Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

1993 • 115 citations

Growth hormone-induced insulin resistance: role of the insulin receptor, IRS-1, GLUT-1, and GLUT-4

1997 • 101 citations

Loss of sensitivity to insulin at early events of the insulin signaling pathway in the liver of growth hormone-transgenic mice

1999 • 87 citations

Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats

1996 • 81 citations

Direct Effects of Growth Hormone on Insulin Action in Rat Adipose Tissue Maintained in Vitro*

1980 • 65 citations

Effect of chronic growth hormone treatment on insulin signal transduction in rat tissues

1997 • 63 citations

The role of phosphoinositide 3-kinase in insulin signalling

1996 • 61 citations

New frontiers in insulin receptor substrate signaling

1995 • 60 citations

Glucose metabolism in transgenic mice containing a chimeric P‐enolpyruvate carboxykinase/bovine growth hormone gene

1993 • 51 citations

Overexpression of bovine growth hormone in transgenic mice is associated with changes in hepatic insulin receptors and in their kinase activity

1996 • 46 citations

EFFECT OF TWO SEROTONIN ANTAGONISTS ON PROLACTIN AND THYROTROPHIN SECRETION IN MAN

1976 • 45 citations

Impact of 2 weeks high dose growth hormone treatment on basal and insulin stimulated substrate metabolism in humans

1993 • 43 citations

Role of hyperinsulinemia on hepatic insulin receptor concentration and autophosphorylation in the presence of high growth hormone levels in transgenic mice overexpressing growth hormone gene

1998 • 40 citations

Recombinant Deoxyribonucleic Acid-Derived 22K- and 20K-Human Growth Hormone Generate Equivalent Diabetogenic Effects during Chronic Infusion in Dogs*

1987 • 33 citations

Plasma Glucagon and Insulin Concentrations in Acromegaly

1980 • 30 citations

Effect of biosynthetic human growth hormone on insulin action in individual tissues of the rat in vivo

1990 • 28 citations

Growth hormone (GH) receptors, binding proteins and IGF-I concentrations in the serum of transgenic mice expressing bovine GH agonist or antagonist

1998 • 25 citations