Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

Ghrelin, a Novel Growth Hormone-Releasing Acylated Peptide, Is Synthesized in a Distinct Endocrine Cell Type in the Gastrointestinal Tracts of Rats and Humans¹

2000 • 1,794 citations

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

2003 • 1,617 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

1997 • 1,137 citations

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

1998 • 1,136 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

2002 • 1,055 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

2004 • 699 citations

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

2000 • 677 citations

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

2001 • 617 citations

Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

1999 • 603 citations

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

1999 • 592 citations

Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway

2003 • 458 citations

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

2002 • 421 citations

Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

2000 • 352 citations

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

2002 • 330 citations

ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors

1997 • 217 citations

Identification of a new G-protein-linked receptor for growth hormone secretagogues.

1996 • 199 citations

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

2002 • 151 citations

Identification of a new G-protein-linked receptor for growth hormone secretagogues

1996 • 131 citations

Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in rats

2003 • 96 citations

Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization

1993 • 88 citations

Neuropeptide Y (NPY) actions on the corticotroph cell of the anterior pituitary gland are not mediated by a direct effect

1998 • 7 citations