Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

1997 • 2,992 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 1,521 citations

Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion

2002 • 1,246 citations

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

2001 • 1,231 citations

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*

1998 • 1,181 citations

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

2001 • 1,181 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

2000 • 878 citations

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

2004 • 699 citations

Post-prandial decrease of circulating human ghrelin levels

2001 • 691 citations

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

2004 • 662 citations

Upregulation of Ghrelin Expression in the Stomach upon Fasting, Insulin-Induced Hypoglycemia, and Leptin Administration

2001 • 629 citations

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

1999 • 592 citations

Minireview: Ghrelin and the Regulation of Energy Balance—A Hypothalamic Perspective

2001 • 556 citations

Insulin Regulates Plasma Ghrelin Concentration

2002 • 500 citations

Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human

1998 • 494 citations

The melanocortin system

2003 • 454 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 454 citations

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

2002 • 394 citations

Serum Ghrelin Levels Are Inversely Correlated with Body Mass Index, Age, and Insulin Concentrations in Normal Children and Are Markedly Increased in Prader-Willi Syndrome

2003 • 380 citations

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

2001 • 372 citations

The influence of insulin on circulating ghrelin

2003 • 368 citations

Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

2000 • 352 citations

Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion

2002 • 342 citations

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

2002 • 330 citations

Growth hormone in obesity

1999 • 313 citations

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice.

2000 • 240 citations

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

2002 • 215 citations

Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans

2002 • 201 citations

Changes in ghrelin and ghrelin receptor expression according to feeding status

2003 • 164 citations

Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective

2001 • 156 citations

Anti-cachectic effect of ghrelin in nude mice bearing human melanoma cells

2003 • 154 citations

Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents

2002 • 146 citations

Insulin Regulates Plasma Ghrelin Concentration

2002 • 131 citations

Ghrelin, Macronutrient Intake and Dietary Preferences in Long–Evans Rats

2002 • 131 citations

Sleep in mice with nonfunctional growth hormone-releasing hormone receptors

2003 • 125 citations

Neuroendocrine and Metabolic Effects of Acute Ghrelin Administration in Human Obesity

2003 • 109 citations

Knockout Studies Defining Different Roles for Melanocortin Receptors in Energy Homeostasis

2003 • 106 citations

Changes in ghrelin and ghrelin receptor expression according to feeding status

2003 • 95 citations

Leptin Modulates Orexigenic Effects of Ghrelin and Attenuates Adiponectin and Insulin Levels and Selectively the Dark-Phase Feeding as Revealed by Central Leptin Gene Therapy

2004 • 94 citations

The GH/IGF-I axis in obesity: influence of neuroendocrine and metabolic factors

2000 • 90 citations

Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice

2003 • 70 citations

Pre-obese and obese agouti mice are sensitive to the anorectic effects of peptide YY3–36 but resistant to ghrelin

2004 • 61 citations

Marked GH secretion after ghrelin alone or combined with GH‐releasing hormone (GHRH) in obese patients

2004 • 55 citations

Neuroendocrine and metabolic determinants of the adaptation of GH/IGF-I axis to obesity.

2002 • 34 citations

Hypothalamo-pituitary-IGF-1 axis in female rats made obese by overfeeding

1997 • 16 citations