Complement C3 receptors: Structure and function

A human leukocyte differentiation antigen family with distinct alpha-subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule.

1983 • 888 citations

RECEPTORS FOR COMPLEMENT ON LEUKOCYTES

1968 • 684 citations

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

1980 • 645 citations

Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

1982 • 615 citations

The role of membrane receptors for C3b and C3d in phagocytosis.

1977 • 536 citations

Primate erythrocyte-immune complex-clearing mechanism.

1983 • 495 citations

The Follicular Dendritic Cell: Its Role in Antigen Presentation in the Generation of Immunological Memory

1980 • 490 citations

The Immune-Adherence Phenomenon

1953 • 487 citations

Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures.

1983 • 474 citations

Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane

1979 • 444 citations

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3.

1981 • 426 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

Characterization of a human B cell-specific antigen (B2) distinct from B1.

1981 • 363 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

Complement receptor (CR1) deficiency in erythrocytes from patients with systemic lupus erythematosus.

1982 • 347 citations

Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes.

1982 • 335 citations

Mode of Inheritance of Decreased C3b Receptors on Erythrocytes of Patients with Systemic Lupus Erythematosus

1982 • 334 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity.

1982 • 296 citations

Complement dependent immune phagocytosis

1968 • 295 citations

Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): mechanism of blockade of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions.

1981 • 292 citations

Release of histamine from rat mast cells by the complement peptides C3a and C5a.

1975 • 290 citations

DEFECTIVE IMMUNE-ADHERENCE (C3b) RECEPTOR ON ERYTHROCYTES FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

1981 • 226 citations

Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies.

1982 • 202 citations

Human platelet activation by C3a and C3a des-arg.

1983 • 196 citations

Severe recurrent bacterial infections associated with defective adherence and chemotaxis in two patients with neutrophils deficient in a cell-associated glycoprotein

1982 • 193 citations

Deficiency of a surface membrane glycoprotein (Mo1) in man.

1984 • 192 citations

The physiological breakdown of the third component of human complement

1980 • 187 citations

A receptor for the third component of complement in the human renal glomerulus

1975 • 185 citations

Deficiency of a Granulocyte-Membrane Glycoprotein (gp150) in a Boy with Recurrent Bacterial Infections

1982 • 180 citations

Analysis of Antigenic Determinants on Human Monocytes and Macrophages

1982 • 179 citations

Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes

1982 • 176 citations

The Alternative Pathway of Complement — A System for Host Resistance to Microbial Infection

1980 • 169 citations

Human anaphylatoxin (C3a) from the third component of complement. Primary structure.

1975 • 161 citations

Development of functional complement receptors during in vitro maturation of human monocytes into macrophages.

1980 • 154 citations

Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 Fragments for Factors B and H, complement receptors , and bovine conglutinin

1983 • 151 citations

Role of Binding Through C3b and IgG in Polymorphonuclear Neutrophil Function: Studies with Trypsin-Generated C3b

1979 • 150 citations

Genetic regulation of a structural polymorphism of human C3b receptor.

1983 • 135 citations

Interaction between human neutrophils and zymosan particles: the role of opsonins and divalent cations.

1981 • 128 citations

Release of endogenous C3b inactivator from lymphocytes in response to triggering membrane receptors for beta 1H globulin.

1980 • 123 citations

Anaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release.

1979 • 122 citations

C3e: An Acidic Fragment of Human C3 with Leukocytosis-Inducing Activity

1979 • 115 citations

Characteristics of isolated erythrocyte complement receptor type one (CR1, C4b-C3b receptor) and CR1-specific antibodies.

1981 • 114 citations

Membrane distribution and adsorptive endocytosis by C3b receptors on human polymorphonuclear leukocytes.

1981 • 112 citations

Interaction of target cell-bound C3bi and C3d with human lymphocyte receptors. Enhancement of antibody-mediated cellular cytotoxicity.

1981 • 109 citations

Augmentation of macrophage complement receptor function in vitro. I. Characterization of the cellular interactions required for the generation of a T-lymphocyte product that enhances macrophage complement receptor function.

1979 • 106 citations

Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer.

1981 • 104 citations

Binding reaction between the third human complement protein and small molecules

1981 • 102 citations

Role of human factor I and C3b receptor in the cleavage of surface‐bound C3bi molecules

1983 • 96 citations

Suppression of T lymphocyte functions by human C3 fragments. I. Inhibition of human T cell proliferative responses by a kallikrein cleavage fragment of human iC3b.

1983 • 93 citations

Ontogeny of human hematopoietic cells: analysis utilizing monoclonal antibodies.

1983 • 91 citations

Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis.

1976 • 90 citations

Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells.

1983 • 83 citations

SERUM-DEPENDENT PHAGOCYTOSIS OF PARAFFIN OIL EMULSIFIED WITH BACTERIAL LIPOPOLYSACCHARIDE

1973 • 83 citations

Lateral distribution and diffusion of the C3b receptor of complement, HLA antigens, and lipid probes in peripheral blood leukocytes.

1980 • 78 citations

Augmentation of macrophage complement receptor function in vitro. III. C3b receptors that promote phagocytosis migrate within the plane of the macrophage plasma membrane.

1981 • 78 citations

Mononuclear phagocyte biology

1984 • 73 citations

The role of C3 fragments in endocytosis and extracellular cytotoxic reactions by polymorphonuclear leukocytes

1982 • 70 citations

Isolation of lymphocyte membrane complement receptor type two (the C3d receptor) and preparation of receptor-specific antibody.

1981 • 69 citations

Lack of binding of human C3, in its native state, to C3b receptors.

1981 • 58 citations

Surface markers of human eosinophils

1976 • 58 citations

Low ionic strength or chemical cross-linking of monomeric C3b increases its binding affinity to the human complement C3b receptor.

1983 • 57 citations

C3d receptors are expressed on human monocytes after in vitro cultivation.

1983 • 52 citations

Homozygous C3 deficiency: Detection of C3 by radioimmunoassay

1977 • 46 citations

The third component of complement inhibits human lymphocyte blastogenesis.

1981 • 45 citations

C3 receptors on human lymphocyte subsets and recruitment of ADCC effector cells by C3 fragments.

1983 • 42 citations

Complement (C3b) interaction with the human granulocyte receptor: correlation of binding of fluid-phase radiolabeled ligand with histaminase release.

1982 • 36 citations

Studies of the Epstein Barr virus receptor found on Raji cells. II. A comparison of lymphocyte binding sites for Epstein Barr virus and C3d.

1983 • 33 citations

Specificity of C3 receptors that mediate phagocytosis by rat peritoneal mast cells.

1981 • 31 citations

An inherited deficiency of the third component of complement, C3, in guinea pigs

1986 • 28 citations

Inhibition of secondary in vitro antibody responses by the third component of complement.

1982 • 24 citations

Modulation of the immune response by anaphylatoxin in the microenvironment of the interacting cells.

1982 • 22 citations

Complement receptor expression by neoplastic and normal human cells.

1983 • 18 citations

Induction of granulocyte histaminase release by particle-bound complement C3 cleavage products (C3b, C3bi) and IgG.

1983 • 15 citations

Release of C3c from bound C3bi by C3b inactivator

1982 • 12 citations