The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines: Figure 1.

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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Induction of apoptosis in fibroblasts by c-myc protein

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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

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Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

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Dissecting p53 tumor suppressor functions in vivo

2002 • 491 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

2002 • 378 citations

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

2002 • 368 citations

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

2003 • 324 citations

Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis

2002 • 270 citations

Degenerative Disorders Caused by Bcl-2 Deficiency Prevented by Loss of Its BH3-Only Antagonist Bim

2001 • 270 citations

Cell metabolism in the regulation of programmed cell death

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Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

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Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

1995 • 187 citations

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.

1991 • 173 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

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Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

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Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas.

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Complementation tagging of cooperating oncogenes in knockout mice

1996 • 41 citations