Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway.

1997 • 747 citations

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1999 • 727 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

The ubiquitin system

1997 • 541 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

1998 • 513 citations

Activation of the cell death program by inhibition of proteasome function

1997 • 494 citations

p53-dependent Induction of Apoptosis by Proteasome Inhibitors

1997 • 473 citations

How the Cyclin Became a Cyclin

1999 • 441 citations

Phosphorylation of p53 Serine 15 Increases Interaction with CBP

1998 • 427 citations

Proteasomes: destruction as a programme

1996 • 373 citations

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1999 • 366 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

1999 • 362 citations

Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53

1999 • 343 citations

Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts

1998 • 340 citations

JNK targets p53 ubiquitination and degradation in nonstressed cells

1998 • 339 citations

Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis.

1996 • 337 citations

Proteasomes play an essential role in thymocyte apoptosis.

1996 • 316 citations

Ubiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation

1997 • 316 citations

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1999 • 296 citations

Inhibition of RNA polymerase II as a trigger for the p53 response

1999 • 287 citations

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway.

1994 • 274 citations

Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.

1996 • 262 citations

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

1994 • 259 citations

Apoptosis induction resulting from proteasome inhibition

1996 • 249 citations

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

1997 • 243 citations

The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.

1996 • 228 citations

Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress

2000 • 223 citations

Eponemycin exerts its antitumor effect through the inhibition of proteasome function.

1999 • 158 citations

mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway.

1998 • 153 citations

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

1995 • 147 citations

An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs

1999 • 133 citations

Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53

1998 • 119 citations

p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts.

1996 • 76 citations

A p53-independent pathway for induction of p21waf1cip1 and concomitant G1 arrest in UV-irradiated human skin fibroblasts.

1997 • 63 citations

Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): Critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram

1989 • 54 citations

Cooperation of a Single Lysine Mutation and a C-terminal Domain in the Cytoplasmic Sequestration of the p53 Protein

1998 • 51 citations

Dose-dependent effects of DNA-damaging agents on p53-mediated cell cycle arrest.

1999 • 46 citations

Mechanism of p53 degradation

1997 • 38 citations

Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin

1997 • 32 citations

Butyrate attenuates BCLX(L) expression in human fibroblasts and acts in synergy with ionizing radiation to induce apoptosis.

1998 • 28 citations