CD4⁺and CD8⁺T Cells Make Discrete Contributions to Demyelination and Neurologic Disease in a Viral Model of Multiple Sclerosis

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination

1975 • 615 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

1983 • 417 citations

Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions

1986 • 383 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

Multiple sclerosis☆Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages

1983 • 309 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

The interferons: Biological effects, mechanisms of action, and use in multiple sclerosis

1995 • 227 citations

Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.

1985 • 207 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.

1986 • 187 citations

Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease

1987 • 164 citations

Demyelination induced by Theiler's virus: influence of the H-2 haplotype.

1985 • 157 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Theiler's virus infection of beta 2-microglobulin-deficient mice

1993 • 141 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody.

1988 • 128 citations

Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses

1988 • 122 citations

Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin.

1993 • 116 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease

1990 • 113 citations

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

1986 • 104 citations

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

1994 • 102 citations

DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice

1984 • 93 citations

Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection

1986 • 89 citations

The balance between persistent virus infection and immune cells determines demyelination.

1996 • 86 citations

Virus-Induced Demyelination in Mice: “Dying Back” of Oligodendrocytes

1985 • 70 citations

Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice

1996 • 68 citations

Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells.

1991 • 66 citations

Observations on demyelinating lesions induced by Theiler's virus in CBA mice

1988 • 58 citations

Neonatal infection with the Daniels strain of Theiler's murine encephalomyelitis virus.

1983 • 57 citations

Immune-mediated injury of virus-infected oligodendrocytes A model of multiple sclerosis

1986 • 45 citations

Spontaneous CNS remyelination in beta 2 microglobulin-deficient mice following virus-induced demyelination

1995 • 39 citations

Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus.

1993 • 38 citations

Differential generation of class I H‐2D‐ versus H‐2K‐restricted cytotoxicity against a demyelinating virus following central nervous system infection

1997 • 36 citations

Neuronal and oligodendroglial infection by the WW strain of Theiler's virus.

1979 • 35 citations

Theiler's virus in brain cell cultures: Lysis of neurons and oligodendrocytes and persistence in astrocytes and macrophages

1986 • 34 citations

Epitope spreading leads to myelin-specific autoimmune responses in SJL mice chronically infected with Theiler's virus.

1997 • 32 citations

Virus-specific intracytoplasmic inclusions in mouse brain produced by a newly isolated strain of Theiler virus. I. Virologic and morphologic studies.

1977 • 31 citations

T-cell development and function in gene-knockout mice

1994 • 27 citations

Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL/J mice

1990 • 25 citations

Multiple sclerosis: a unique immunopathological syndrome of the central nervous system

1995 • 23 citations

Theiler's virus-associated antigens on the surfaces of cultured glial cells

1988 • 18 citations

Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures

1990 • 15 citations

Growth of the WW strain of Theiler virus in mouse central nervous system organotypic culture

1979 • 14 citations

H-2 Antigens

1987 • 13 citations

The Contribution of MHC Gene Products to Demyelination by Theiler’s Virus

1987 • 7 citations

Deleted Work

1955 • 0 citations