Statins Promote Potent Systemic Antioxidant Effects Through Specific Inflammatory Pathways

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial

2002 • 6,780 citations

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Upregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors

1998 • 1,860 citations

Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease

1994 • 1,697 citations

Measurement of C-Reactive Protein for the Targeting of Statin Therapy in the Primary Prevention of Acute Coronary Events

2001 • 1,537 citations

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

1999 • 1,488 citations

Pleiotropic Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

2001 • 1,290 citations

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

1994 • 1,274 citations

Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease

2001 • 920 citations

3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.

1997 • 840 citations

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

2001 • 783 citations

The oxidative modification hypothesis of atherogenesis: an overview

2000 • 749 citations

Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes

2001 • 690 citations

Myeloperoxidase-generated oxidants and atherosclerosis

2000 • 607 citations

Cellular Antioxidant Effects of Atorvastatin In Vitro and In Vivo

2002 • 590 citations

Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro

1999 • 492 citations

A Tale of Two Controversies

2002 • 484 citations

Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?

2002 • 476 citations

Hypochlorous Acid Oxygenates the Cysteine Switch Domain of Pro-matrilysin (MMP-7)

2001 • 473 citations

Reactive Nitrogen Intermediates Promote Low Density Lipoprotein Oxidation in Human Atherosclerotic Intima

1997 • 470 citations

Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy

2003 • 453 citations

Stable markers of oxidant damage to proteins and their application in the study of human disease

1999 • 451 citations

Myeloperoxidase Functions as a Major Enzymatic Catalyst for Initiation of Lipid Peroxidation at Sites of Inflammation

2002 • 427 citations

Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases

2000 • 403 citations

Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques

1997 • 355 citations

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

1994 • 334 citations

Tocopherol‐mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement

1999 • 301 citations

Effects of Vitamin E on Lipid Peroxidation in Healthy Persons

2001 • 274 citations

Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation

1994 • 269 citations

Consequences of Total and Subtotal Myeloperoxidase Deficiency: Risk or Benefit ?

2000 • 258 citations

A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians

2001 • 213 citations

Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders

1999 • 152 citations

Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.

1992 • 114 citations

Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress 1,2 1This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Earl Stadtman

2002 • 111 citations

Is the Emperor Wearing Clothes?

2001 • 102 citations

Are statins anti-inflammatory?

2000 • 100 citations

Defects in leukocyte-mediated initiation of lipid peroxidation in plasma as studied in myeloperoxidase-deficient subjects: systematic identification of multiple endogenous diffusible substrates for myeloperoxidase in plasma

2002 • 94 citations

α‐Tocopherol does not inhibit hypochlorite‐induced oxidation of apolipoprotein B‐100 of low‐density lipoprotein

1997 • 78 citations

Nitric oxide is a substrate for mammalian peroxidases

2000 • 57 citations

Deleted Work

1955 • 0 citations