Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing

1988 • 485 citations

Herpes simplex virus type 1 ICP27 is an essential regulatory protein

1985 • 462 citations

Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110

1986 • 422 citations

Herpes simplex virus virion host shutoff function

1988 • 350 citations

Evidence for a direct role for both the 175,000- and 110,000-molecular-weight immediate-early proteins of herpes simplex virus in the transactivation of delayed-early promoters

1985 • 345 citations

A generalized technique for deletion of specific genes in large genomes: a gene 22 of herpes simplex virus 1 is not essential for growth

1981 • 336 citations

Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture

1987 • 333 citations

Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient

1989 • 329 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses

1992 • 299 citations

Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides

1983 • 293 citations

Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs.

1987 • 292 citations

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression

1992 • 280 citations

Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.

1994 • 278 citations

Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.

1985 • 267 citations

Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27

1990 • 247 citations

The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)

1994 • 243 citations

Detailed analysis of the portion of the herpes simplex virus type 1 genome encoding glycoprotein C

1983 • 230 citations

A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing.

1992 • 207 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

The herpes simplex virus type 1 alpha protein ICP27 can act as a trans-repressor or a trans-activator in combination with ICP4 and ICP0

1988 • 202 citations

Suppression of the Synthesis of Cellular Macromolecules by Herpes Simplex Virus

1978 • 194 citations

Characterization of the IE110 Gene of Herpes Simplex Virus Type 1

1986 • 192 citations

The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection

1994 • 189 citations

The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.

1994 • 185 citations

Individual HSV Transcripts

1985 • 176 citations

Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27

1988 • 167 citations

The Products of Herpes Simplex Virus Type 1 (HSV-1) Immediate Early Genes 1, 2 and 3 Can Activate HSV-1 Gene Expression in trans

1986 • 163 citations

A binding consensus: RNA-protein interactions in splicing, snRNPs, and sex

1989 • 162 citations

Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA

1994 • 159 citations

The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection

1988 • 153 citations

Effects of herpes simplex virus on mRNA stability

1987 • 151 citations

Analysis of the functional domains of herpes simplex virus type 1 immediate-early polypeptide Vmw110

1988 • 139 citations

Polysomes and Protein Synthesis in Cells Infected with a DNA Virus

1966 • 135 citations

A detailed mutational analysis of Vmw110, a trans-acting transcriptional activator encoded by herpes simplex virus type 1.

1987 • 135 citations

Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing

1992 • 125 citations

The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection

1990 • 124 citations

Herpes simplex virus type 1 glycoprotein C-negative mutants exhibit multiple phenotypes, including secretion of truncated glycoproteins

1984 • 122 citations

Requirement of protein synthesis for the degradation of host mRNA in Friend erythroleukemia cells infected wtih herpes simplex virus type 1

1978 • 113 citations

The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus

1967 • 110 citations

A Truncated Form of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Is Expressed in a Cell Type Dependent Manner

1993 • 104 citations

Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1

1993 • 101 citations

Herpes simplex Virus a Protein ICP27 Can Inhibit or Augment Viral Gene Transactivation

1989 • 94 citations

Early Virion-associated Suppression of Cellular Protein Synthesis by Herpes Simplex Virus is Accompanied by Inactivation of mRNA

1984 • 94 citations

Early and Delayed Shut-off of Host Protein Synthesis in Cells Infected with Herpes Simplex Virus

1982 • 93 citations

Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors

1987 • 92 citations

Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities

1989 • 92 citations

A mutant of herpes simplex virus type 1 exhibits increased stability of immediate-early (alpha) mRNAs

1987 • 88 citations

Herpes simplex virus induces a processing factor that stimulates poly(A) site usage

1989 • 84 citations

The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule

1989 • 83 citations

Correspondence Between a Mammalian Spliceosome Component and an Essential Yeast Splicing Factor

1993 • 81 citations

Transactivation of plasmid-borne promoters by adenovirus and several herpes group viruses

1984 • 81 citations

Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.

1992 • 81 citations

Structures of two spliced herpes simplex virus type 1 immediate-early mRNA's which map at the junctions of the unique and reiterated regions of the virus DNA S component

1981 • 80 citations

Interaction Between PRP11 and SPP91 Yeast Splicing Factors and Characterization of a PRP9-PRP11-SPP91 Complex

1993 • 73 citations

An unusual spliced herpes simplex virus type 1 transcript with sequence homology to Epstein-Barr virus DNA

1985 • 71 citations

Construction and properties of a viable herpes simplex virus 1 recombinant lacking coding sequences of the alpha 47 gene

1986 • 65 citations

Herpes simplex virus types 1 and 2 induce shutoff of host protein synthesis by different mechanisms in Friend erythroleukemia cells

1983 • 44 citations

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant

1991 • 41 citations

The herpes simplex virus immediate early protein ICP27 encodes a potential metal binding domain and binds zinc in vitro

1992 • 38 citations

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0

1992 • 29 citations

The cDNA of UL15, a highly conserved herpes simplex virus 1 gene, effectively replaces the two exons of the wild-type virus

1992 • 26 citations

Antiviral properties of a dominant negative mutant of the herpes simplex virus type 1 regulatory protein ICP0

1992 • 24 citations

Change of processing and nucleocytoplasmic transport of mRNA in HSV-1-infected cells

1989 • 23 citations

Altered Properties of the Herpes Simplex Virus ICP8 DNA-Binding Protein in Cells Infected with ICP27 Mutant Viruses

1993 • 21 citations

Isolation and characterization of a functional cDNA encoding ICP0 from herpes simplex virus type 1

1991 • 15 citations