Prevalence of Molecular Mechanisms of Resistance to Azole Antifungal Agents in Candida albicans Strains Displaying High-Level Fluconazole Resistance Isolated from Human Immunodeficiency Virus-Infected Patients

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Clinical, Cellular, and Molecular Factors That Contribute to Antifungal Drug Resistance

1998 • 1,360 citations

Development of Interpretive Breakpoints for Antifungal Susceptibility Testing: Conceptual Framework and Analysis of In Vitro-In Vivo Correlation Data for Fluconazole, Itraconazole, and Candida Infections

1997 • 862 citations

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

1995 • 805 citations

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1997 • 608 citations

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene

1997 • 578 citations

Antifungal agents: chemotherapeutic targets and immunologic strategies

1996 • 491 citations

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

1995 • 476 citations

Amino Acid Substitutions in the Cytochrome P-450 Lanosterol 14α-Demethylase (CYP51A1) from Azole-Resistant Candida albicans Clinical Isolates Contribute to Resistance to Azole Antifungal Agents

1998 • 451 citations

Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

1996 • 407 citations

Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

1999 • 357 citations

Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical Candida albicans Strains

1998 • 336 citations

The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14alpha demethylase in Candida albicans

1997 • 291 citations

Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance

1996 • 262 citations

Molecular mechanisms of drug resistance in fungi

1994 • 254 citations

Computer-assisted methods for assessing strain relatedness in Candida albicans by fingerprinting with the moderately repetitive sequence Ca3

1990 • 224 citations

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

1998 • 206 citations

A Three-Dimensional Model of Lanosterol 14α-Demethylase of Candida albicans and Its Interaction with Azole Antifungals

2000 • 203 citations

The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity

1997 • 200 citations

Diethylcarbamazine-related antimicrobial activity in Mycobacterium tuberculosis-infected blood

1998 • 183 citations

Rapid, Transient Fluconazole Resistance in Candida albicans Is Associated with Increased mRNA Levels of CDR

1998 • 167 citations

Genetics and biochemistry of yeast multidrug resistance

1994 • 157 citations

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

2006 • 144 citations

The R467K Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

2000 • 132 citations

Molecular aspects of fluconazole resistance development in Candida albicans

1999 • 129 citations

Mutation in cytochrome P-450-dependent 14α-demethylase results in decreased affinity for azole antifungals

1990 • 118 citations

Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains

1997 • 117 citations

The G464S Amino Acid Substitution in Candida albicans Sterol 14α-Demethylase Causes Fluconazole Resistance in the Clinic through Reduced Affinity

1999 • 116 citations

Y132H substitution inCandida albicanssterol 14α-demethylase confers fluconazole resistance by preventing binding to haem

1999 • 114 citations

Detection and Significance of Fluconazole Resistance in Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients

1996 • 111 citations

Nucleotide sequence of cytochrome P450 LIAI (lanosterol 14α-demethylase) fromCandida albicans

1989 • 106 citations

Formation of Azole-Resistant Candida albicans by Mutation of Sterol 14-Demethylase P450

1999 • 101 citations

Multiple resistance mechanisms to azole antifungals in yeast clinical isolates

1998 • 99 citations

Multiple Resistant Phenotypes of Candida albicans Coexist during Episodes of Oropharyngeal Candidiasis in Human Immunodeficiency Virus-Infected Patients

1999 • 97 citations

Multiple amino acid substitutions in lanosterol 14α-demethylase contribute to azole resistance in Candida albicans

1999 • 95 citations

Simple method for detecting fluconazole-resistant yeasts with chromogenic agar

1996 • 71 citations

Resistance to fluconazole inCandida albicansfrom AIDS patients correlated with reduced intracellular accumulation of drug

1995 • 70 citations

Clinical Evaluation and Microbiology of Oropharyngeal Infection Due to Fluconazole‐ResistantCandidain Human Immunodeficiency Virus–Infected Patients

1998 • 66 citations

Modeling cytochrome P450 14α demethylase (Candida albicans) from P450cam

1994 • 66 citations

Correlation between In Vitro and In Vivo Antifungal Activities in Experimental Fluconazole-Resistant Oropharyngeal and Esophageal Candidiasis

2000 • 47 citations

Comparative evaluation of macrodilution and chromogenic agar screening for determining fluconazole susceptibility of Candida albicans

1996 • 29 citations

Comparison of DNA-based typing methods to assess genetic diversity and relatedness among Candida albicans clinical isolates.

2000 • 29 citations

Amino acid variations of cytochrome P-450 lanosterol 14 alpha-demethylase (CYP51A1) from fluconazoleresistant clinical isolates of Candida albicans.

1999 • 12 citations

Pharmacokinetics and distribution in tissue of FK-037, a new parenteral cephalosporin

1994 • 9 citations