Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors

Molecular cloning: A laboratory manual

1990 • 85,659 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities.

1984 • 386 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures.

1990 • 262 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi.

1990 • 238 citations

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

1989 • 228 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

A microplaque reduction assay for human and mouse interferon

1975 • 158 citations

Interferon-gamma: A Review

1989 • 156 citations

B cell growth and differentiation activity of interleukin‐hp1 and related murine plasmacytoma growth factors. synergy with interleukin 1

1988 • 125 citations

Tcgfiii/p40 is produced by naive murine cd4+ t cells but is not a general t cell growth factor*

1989 • 115 citations

Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4.

1989 • 93 citations

Evidence for mouse Th1- and Th2-like helper T cells in vivo. Selective reduction of Th1-like cells after total lymphoid irradiation.

1989 • 68 citations

Induction of antigen-specific antibody responses in primed and unprimed B cells. Functional heterogeneity among Th1 and Th2 T cell clones.

1989 • 57 citations

Cytotoxic T cell responses to haptenated cells III. Isolation and specificity analysis of continuously growing clones

1980 • 54 citations

Enumeration of single IFN-gamma-producing cells in mice during viral and bacterial infection.

1989 • 50 citations

Development of T cell clones reactive to two defined restriction elements in conjunction with two defined epitopes of antigen

1985 • 23 citations

Enumeration of cytokine‐secreting cells at the single‐cell level

1989 • 23 citations

Different response of T_H1 cells for stimulation with anti‐CD3 antibodies

1990 • 22 citations

Correlation between the biologic functions and the generation of lymphokines in T cell clones.

1989 • 7 citations