Exaggerated Proinflammatory and Th1 Responses in the Absence of γ/δ T Cells after Infection withListeria monocytogenes

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection

2000 • 1,107 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations.

1995 • 554 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Impaired NK1+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice

1997 • 494 citations

Specific immunity to listeria monocytogenes in the absence of IFNγ

1995 • 432 citations

Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen

1993 • 426 citations

Activation events during thymic selection.

1992 • 326 citations

Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1991 • 321 citations

Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma.

1994 • 305 citations

An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis.

1997 • 302 citations

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.

1996 • 268 citations

NK1.1⁺ CD4⁺ CD8‐ thymocytes with specific lymphokine secretion

1993 • 265 citations

NK Markers Are Expressed on a High Percentage of Virus-Specific CD8+ and CD4+ T Cells

2000 • 250 citations

Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia.

1996 • 250 citations

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium.

1996 • 242 citations

Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

1996 • 237 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

Rapid Recruitment of Neutrophils Containing Prestored IL-12 During Microbial Infection

2000 • 223 citations

Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells.

1990 • 213 citations

Immunoregulatory Functions of γδ T Cells

1998 • 201 citations

Immune protection and control of inflammatory tissue necrosis by gamma delta T cells.

1994 • 189 citations

Cutting edge: protective response to pulmonary injury requires gamma delta T lymphocytes.

1999 • 163 citations

Endogenous tumor necrosis factor, interleukin-6, and gamma interferon levels during Listeria monocytogenes infection in mice

1992 • 147 citations

Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection.

1993 • 144 citations

Vγ1+ T Cells Suppress and Vγ4+ T Cells Promote Susceptibility to Coxsackievirus B3-Induced Myocarditis in Mice

2000 • 139 citations

Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12.

1995 • 134 citations

γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis

1995 • 134 citations

Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction.

1998 • 126 citations

Cutting Edge: Protective Response to Pulmonary Injury Requires γδ T Lymphocytes

1999 • 126 citations

Crosstalk between alpha/beta T cells and gamma/delta T cells in vivo: activation of alpha/beta T-cell responses after gamma/delta T-cell modulation with the monoclonal antibody GL3.

1993 • 118 citations

Downmodulation of the Inflammatory Response to Bacterial Infection by γδ T Cells Cytotoxic for Activated Macrophages

2000 • 118 citations

Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines.

2000 • 115 citations

Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of alpha beta and gamma delta T cells.

1995 • 112 citations

Apoptosis of Fashigh CD4+ Synovial T Cells by Borrelia-reactive Fas-ligandhigh γδ T Cells in Lyme Arthritis

1996 • 106 citations

Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis.

1998 • 105 citations

Involvement of NK1+ T Cells and Their IFN-γ Production in the Generalized Shwartzman Reaction

1998 • 105 citations

IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes

1999 • 97 citations

Activation of C-C β-chemokines in human peripheral blood γδ T cells by isopentenyl pyrophosphate and regulation by cytokines

2000 • 88 citations

Adaptive Immunity and Enhanced CD8+ T Cell Response toListeria monocytogenesin the Absence of Perforin and IFN-γ

2000 • 88 citations

Depletion of a γδ T Cell Subset Can Increase Host Resistance to a Bacterial Infection

2000 • 86 citations

Differing Roles of Inflammation and Antigen in T Cell Proliferation and Memory Generation

2000 • 84 citations

Involvement of the Fas/Fas Ligand Pathway in Activation-Induced Cell Death of Mycobacteria-Reactive Human γδ T Cells: A Mechanism for the Loss of γδ T Cells in Patients with Pulmonary Tuberculosis

1998 • 82 citations

Cytokine Production by Vγ⁺-T-Cell Subsets Is an Important Factor Determining CD4⁺-Th-Cell Phenotype and Susceptibility of BALB/c Mice to Coxsackievirus B3-Induced Myocarditis

2001 • 79 citations

The role of γδ T cells in priming macrophages to produce tumor necrosis factor‐α

1995 • 74 citations

Early IFN-gamma production and innate immunity during Listeria monocytogenes infection in the absence of NK cells.

1998 • 65 citations

γδ cells regulate autoimmunity

1997 • 61 citations

Disruption of the Cellular Inflammatory Response toListeria monocytogenesInfection in Mice with Disruptions in Targeted Genes

1998 • 61 citations

Early IFN-γ Production and Innate Immunity DuringListeria monocytogenesInfection in the Absence of NK Cells

1998 • 54 citations

Inflammation alone evokes the response of a TCR-invariant mouse gamma delta T cell subset.

1999 • 49 citations

Inflammation Alone Evokes the Response of a TCR-Invariant Mouse γδ T Cell Subset

1999 • 38 citations

Analysis of the role of natural killer cells in Listeria monocytogenes infection: relation between natural killer cells and T-cell receptor gamma delta T cells in the host defence mechanism at the early stage of infection.

1994 • 38 citations

Conventional αβ T Cells Are Sufficient for Innate and Adaptive Immunity Against Enteric Listeria monocytogenes

2001 • 34 citations

The presentation of class I and class II epitopes of listeriolysin O is regulated by intracellular localization and by intercellular spread of Listeria monocytogenes.

1996 • 31 citations

In vivo administration of anti-asialo-GM1 antibody enhances splenic clearance of Listeria monocytogenes.

1990 • 11 citations