Technology Insight: targeting of biological molecules for evaluation of high-risk atherosclerotic plaques with magnetic resonance imaging

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Hemodynamic Shear Stress and Its Role in Atherosclerosis

1999 • 3,339 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.

1986 • 1,323 citations

INFLUENCE OF PLAQUE CONFIGURATION AND STRESS DISTRIBUTION ON FISSURING OF CORONARY ATHEROSCLEROTIC PLAQUES

1989 • 1,249 citations

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1997 • 1,210 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi.

1983 • 1,023 citations

Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.

1990 • 1,017 citations

Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes

2001 • 798 citations

Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging

2003 • 794 citations

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

2003 • 695 citations

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

1999 • 619 citations

Magnetic Resonance Imaging of Atherosclerotic Plaque With Ultrasmall Superparamagnetic Particles of Iron Oxide in Hyperlipidemic Rabbits

2001 • 602 citations

Novel MRI Contrast Agent for Molecular Imaging of Fibrin

2001 • 518 citations

Identification of 92-kD Gelatinase in Human Coronary Atherosclerotic Lesions

1995 • 495 citations

Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.

1990 • 493 citations

Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.

2003 • 377 citations

Cellular microparticles: new players in the field of vascular disease?

2004 • 361 citations

Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E ₂ -Dependent Plaque Instability

2001 • 349 citations

Insights into the use of paramagnetic Gd(III) complexes in MR‐molecular imaging investigations

2002 • 323 citations

Matrix metalloproteinases A review of their structure and role in acute coronary syndrome

2003 • 305 citations

Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI

2004 • 274 citations

Magnetic resonance contrast enhancement of neovasculature with ?v?3-targeted nanoparticles

2000 • 274 citations

Angiogenesis in human coronary atherosclerotic plaques.

1994 • 273 citations

Differential Accumulation of Proteoglycans and Hyaluronan in Culprit Lesions

2002 • 267 citations

Endothelial dysfunction and atherosclerosis

1997 • 250 citations

High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent

2000 • 239 citations

Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system.

1987 • 231 citations

Seeing Within

2004 • 195 citations

Lipid-Rich Atherosclerotic Plaques Detected by Gadofluorine-Enhanced In Vivo Magnetic Resonance Imaging

2004 • 195 citations

Improved molecular imaging contrast agent for detection of human thrombus

2003 • 186 citations

CD36, a Novel Receptor for Oxidized Low-Density Lipoproteins, Is Highly Expressed on Lipid-Laden Macrophages in Human Atherosclerotic Aorta

1999 • 176 citations

Detection of Atherosclerotic Plaque With Gadofluorine-Enhanced Magnetic Resonance Imaging

2003 • 167 citations

Tenascin-C Is Expressed in Macrophage-Rich Human Coronary Atherosclerotic Plaque

1999 • 156 citations

Macrophage Accumulation Associated With Rat Cardiac Allograft Rejection Detected by Magnetic Resonance Imaging With Ultrasmall Superparamagnetic Iron Oxide Particles

2001 • 155 citations

Analysis of Macrophage Scavenger Receptor (SR-A) Expression in Human Aortic Atherosclerotic Lesions

1999 • 136 citations

Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo

1999 • 134 citations

In Vivo Uptake of Radiolabeled MDA2, an Oxidation-Specific Monoclonal Antibody, Provides an Accurate Measure of Atherosclerotic Lesions Rich in Oxidized LDL and Is Highly Sensitive to Their Regression

2000 • 121 citations

Superparamagnetic Iron Oxide–Based Method for Quantifying Recruitment of Monocytes to Mouse Atherosclerotic Lesions In Vivo

2003 • 121 citations

A targeted contrast agent for magnetic resonance imaging of thrombus: Implications of spatial resolution

2001 • 110 citations

Inhibition of tissue factor limits the growth of venous thrombus in the rabbit

2003 • 83 citations

Can receptors be imaged with MRI agents?

1997 • 74 citations

Noninvasive imaging of oxidized Low-Density Lipoprotein in atherosclerotic plaques with tagged oxidation-specific antibodies

2002 • 52 citations

USPIO-enhanced Direct MR Imaging of Thrombus: Preclinical Evaluation in Rabbits

2001 • 43 citations

Cytochemical changes in a human arterial proteoglycan related to atherosclerosis

1989 • 19 citations