Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability.

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

1989 • 770 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

1997 • 627 citations

An Introduction to Cardiovascular Physiology

1991 • 566 citations

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1970 • 546 citations

Angiogenesis and angiogenesis inhibition: An overview

1997 • 419 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

1999 • 332 citations

A transparent access chamber for the rat dorsal skin fold

1979 • 287 citations

Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.

1999 • 260 citations

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.

1995 • 219 citations

In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

1999 • 215 citations

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia

1999 • 183 citations

The interaction with tubulin of a series of stilbenes based on combretastatin A-4

1995 • 175 citations

Vinca alkaloids: Anti-vascular effects in a murine tumour

1993 • 171 citations

Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo.

2001 • 169 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy

1998 • 135 citations

Tumour vasculature as a target for cancer therapy.

1999 • 119 citations

Nitric oxide production by tumour tissue: impact on the response to photodynamic therapy

2000 • 115 citations

Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate.

2001 • 112 citations

Perivascular oxygen tensions in a transplantable mammary tumor growing in a dorsal flap window chamber.

1992 • 103 citations

Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

1997 • 101 citations

Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status

1998 • 101 citations

The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors

1998 • 98 citations

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.

2000 • 83 citations

Evaluation of Carbocyanine-Labeled Erythrocytes for Microvascular Measurements

1993 • 70 citations

Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: relation to vascular effects.

1997 • 67 citations

The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment

1993 • 54 citations

Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide

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Effect of colchicine on human carcinoma

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Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia.

1991 • 51 citations

Modification of tumour blood flow using the hypertensive agent, angiotensin II

1993 • 45 citations

Ischemia reperfusion injury in tumors: the role of oxygen radicals and nitric oxide.

1995 • 45 citations

Red Blood Cell Behavior at Low Flow Rate in Microvessels

1999 • 32 citations

Characterisation of tumour blood flow using a 'tissue-isolated' preparation

1994 • 29 citations

Locomotory response ofPhreatichthys andruzzii Vinciguerra (Pisces, Cyprinidae) to chemical signals of conspecifics and of closely related species

1989 • 26 citations

Temporal Effects of 5.0 Gy Radiation in Healing Subcutaneous Microvasculature of a Dorsal Flap Window Chamber

1987 • 22 citations