Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate.

A computer program for comparing K samples with right-censored data

1972 • 731 citations

Combined effects of angiostatin and ionizing radiation in antitumour therapy

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Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support

1993 • 665 citations

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

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Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

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Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

The next frontier of molecular medicine: Delivery of therapeutics

1998 • 408 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

1999 • 332 citations

Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.

1999 • 260 citations

Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.

1998 • 244 citations

In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug

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Targeting tumour vasculature: the development of combretastatin A4

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Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature.

1993 • 203 citations

Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies.

1991 • 200 citations

Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4.

1998 • 154 citations

Synergy between an antiangiogenic integrin α_vantagonist and an antibody–cytokine fusion protein eradicates spontaneous tumor metastases

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Radioimmunotherapy of metastatic colorectal tumours with iodine-131-labelled antibody to carcinoembryonic antigen: phase I/II study with comparative biodistribution of intact and F(ab')2 antibodies

1994 • 97 citations

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma.

2000 • 83 citations

Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

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Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents.

1996 • 74 citations

Colchicine in the Experimental Chemotherapy of Cancer

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Relationship between tumour size and uptake of radiolabelled anti-CEA in a colon tumour xenograft

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Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent.

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Control of differentiation in human colorectal carcinoma cell lines: Epithelial—mesenchymal interactions

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Oxygen tension measurements of tumors growing in mice

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A mathematical evaluation of tumour growth curves in rapid, intermediate and slow growing rat hepatomata

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A novel technique, using radioluminography, for the measurement of uniformity of radiolabelled antibody distribution in a colorectal cancer xenograft model

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A comparison of image registration techniques for the correlation of radiolabelled antibody distribution with tumour morphology

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Effectiveness of radiolabelled antibodies for radio-immunotherapy in a colorectal xenograft model: a comparative study using the linear–quadratic formulation

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Pharmacokinetics of Monoclonal Antibodies

1996 • 5 citations