CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility DuringToxoplasma gondiiInfection

Infectious Diseases of the Fetus and Newborn Infant

1984 • 2,479 citations

The Biology of Chemokines and their Receptors

2000 • 2,416 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Regulation and Function of T-Cell-Mediated Immunity duringToxoplasma gondiiInfection

1998 • 685 citations

Neutrophil and B Cell Expansion in Mice That Lack the Murine IL-8 Receptor Homolog

1994 • 666 citations

Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

1993 • 627 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: Clinical and neuropathological findings in 27 patients

1986 • 485 citations

Impaired Host Defense, Hematopoiesis, Granulomatous Inflammation and Type 1–Type 2 Cytokine Balance in Mice Lacking CC Chemokine Receptor 1

1997 • 454 citations

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

1995 • 446 citations

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

1997 • 432 citations

Identification and characterization of macrophage inflammatory protein 2.

1989 • 432 citations

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

1996 • 398 citations

Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

2000 • 384 citations

Flow cytometric identification of murine neutrophils and monocytes

1996 • 357 citations

Chemokine binding and activities mediated by the mouse IL-8 receptor.

1995 • 355 citations

Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen,Toxoplasma gondii

2000 • 296 citations

CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in MurinePseudomonas aeruginosaPneumonia

2000 • 273 citations

Neutrophils Play a Protective Nonphagocytic Role in SystemicMycobacterium tuberculosisInfection of Mice

2000 • 268 citations

The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.

1994 • 262 citations

Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation.

1991 • 262 citations

Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

1997 • 236 citations

Rapid Recruitment of Neutrophils Containing Prestored IL-12 During Microbial Infection

2000 • 223 citations

IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii

2000 • 220 citations

Early Recruitment of Neutrophils Determines Subsequent T1/T2 Host Responses in a Murine Model ofLegionella pneumophilaPneumonia

2001 • 217 citations

Interleukin 8 Receptor Deficiency Confers Susceptibility to Acute Experimental Pyelonephritis and May Have a Human Counterpart

2000 • 198 citations

In vivo inflammatory activity of neutrophil-activating factor, a novel chemotactic peptide derived from human monocytes.

1989 • 198 citations

Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii

1997 • 197 citations

An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

1997 • 194 citations

Leukocyte specificity and binding of human neutrophil attractant/activation protein-1.

1990 • 189 citations

Transepithelial Neutrophil Migration Is CXCR1 Dependent In Vitro and Is Defective in IL-8 Receptor Knockout Mice

2000 • 187 citations

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.

1997 • 183 citations

Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens.

1999 • 174 citations

Neutrophil Depletion duringToxoplasma gondiiInfection Leads to Impaired Immunity and Lethal Systemic Pathology

2001 • 163 citations

Chemokine-Dependent Neutrophil Recruitment in a Murine Model ofLegionellaPneumonia: Potential Role of Neutrophils as Immunoregulatory Cells

2001 • 151 citations

Human Polymorphonuclear Leukocytes Produce IL-12, TNF-α, and the Chemokines Macrophage-Inflammatory Protein-1α and -1β in Response toToxoplasma gondiiAntigens

1999 • 141 citations

Interleukin‐8 Receptor Knockout Mice Have Subepithelial Neutrophil Entrapment and Renal Scarring following Acute Pyelonephritis

2000 • 135 citations

Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12.

1999 • 125 citations

Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria

2000 • 120 citations

Genomic Structure, Promoter Sequence, and Induction of Expression of the Mouse Nramp1 Gene in Macrophages

1995 • 107 citations

Murine Neutrophil Stimulation byToxoplasma gondiiAntigen Drives High Level Production of IFN-γ-Independent IL-12

1999 • 103 citations

Neutrophil depletion exacerbates experimental Chagas' disease in BALB / c, but protects C57BL / 6 mice through modulating the Th1 / Th2 dichotomy in different directions

2001 • 98 citations

Ca2+-Dependent Production and Release of IL-8 in Human Neutrophils

1998 • 97 citations

Mice Lacking the Chemokine Receptor CCR1 Show Increased Susceptibility toToxoplasma gondiiInfection

2001 • 90 citations

Immunoregulation during Toxoplasmosis

1998 • 81 citations

Induction of early-response genes KC and JE by mycobacterial lipoarabinomannans: regulation of KC expression in murine macrophages by Lsh/Ity/Bcg (candidate Nramp)

1994 • 75 citations

Initiation of T-Helper Cell Immunity to Candida albicans by IL-12: The Role of Neutrophils

1997 • 75 citations

Exacerbation of toxoplasmosis in neutrophil-depleted mice.

1996 • 70 citations

The Murine Homologue of the Human Interleukin-8 Receptor Type B Maps near the Ity-Lsh-Bcg Disease Resistance Locus

1993 • 62 citations

Mucosal and systemic candidiasis in IL-8Rh−/− BALB/c mice

1999 • 49 citations

Influence of macrophage resistance geneLsh/Ity/Bcg(candidateNramp) onToxoplasma gondiiinfection in mice

1994 • 25 citations

Mouse peritoneal macrophages: Characterization of functional subsets following Percoll density gradients

1993 • 23 citations

Neutrophil chemotactic factors secreted fromToxoplasma gondii

1991 • 8 citations