Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii

1988 • 1,150 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

1996 • 920 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.

1995 • 537 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha

1994 • 374 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii.

1996 • 333 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

Failure to trigger the oxidative metabolic burst by normal macrophages: possible mechanism for survival of intracellular pathogens.

1980 • 322 citations

Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.

1993 • 249 citations

Western Blot analysis of the antigens of Toxoplasma gondii recognized by human IgM and IgG antibodies.

1983 • 231 citations

Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy.

1993 • 228 citations

Toxoplasma gondii infection of the central nervous system

1981 • 193 citations

Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen

1993 • 147 citations

IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections.

1993 • 137 citations

Potential role for interleukin-10 in the immunosuppression associated with kala azar.

1993 • 131 citations

Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates

1994 • 116 citations

IL‐10 mediates immunosuppression following primary infection with Toxoplasma gondii in mice

1995 • 109 citations

Plasmodium chabaudi chabaudi:Differential Susceptibility of Gene-Targeted Mice Deficient in IL-10 to an Erythrocytic-Stage Infection

1996 • 101 citations

Natural killer cells induced by acute and chronic toxoplasma infection

1982 • 97 citations

Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii

1993 • 88 citations

Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice.

1996 • 85 citations

SCID mouse models of acute and relapsing chronic Toxoplasma gondii infections

1992 • 79 citations

Roles of gamma interferon and other cytokines in suppression of the spleen cell proliferative response to concanavalin A and toxoplasma antigen during acute toxoplasmosis

1995 • 77 citations

Functional and Quantitative Alterations in T Lymphocyte Subpopulations in Acute Toxoplasmosis

1984 • 76 citations

Increased natural killer cell activity in experimental American trypanosomiasis.

1981 • 72 citations

Role of macrophage–derived nitric oxide in suppression of lymphocyte proliferation during blood–stage malaria

1995 • 69 citations

Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice.

1993 • 65 citations

Interleukin 10: An overview

1992 • 59 citations

Human lymphokine-activated killer cells are cytotoxic against cells infected with Toxoplasma gondii.

1992 • 58 citations

Gamma interferon-dependent temporary resistance to acute Toxoplasma gondii infection independent of CD4+ or CD8+ lymphocytes

1993 • 53 citations

IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice.

1994 • 44 citations

Simple technique for the direct isolation of toxoplasma tissue cysts from fetal ovine brain

1983 • 41 citations

Different regulation of the L3T4-T cell subset by B cells in different mouse strains bearing the H-2k haplotype.

1986 • 37 citations

Demonstration of T-Cell dysfunction during acute toxoplasma infection

1986 • 36 citations

Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection

1995 • 12 citations

Nitric oxide production by splenic macrophages is not responsible for T cell suppression during acute infection with lactate dehydrogenase-elevating virus.

1994 • 10 citations