Neutrophil Depletion duringToxoplasma gondiiInfection Leads to Impaired Immunity and Lethal Systemic Pathology

Infectious Diseases of the Fetus and Newborn Infant

1984 • 2,479 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Regulation and Function of T-Cell-Mediated Immunity duringToxoplasma gondiiInfection

1998 • 685 citations

Development of Th1-Inducing Capacity in Myeloid Dendritic Cells Requires Environmental Instruction

2000 • 514 citations

Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: Clinical and neuropathological findings in 27 patients

1986 • 485 citations

Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii

1997 • 432 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

1996 • 398 citations

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

1994 • 352 citations

Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha.

1990 • 290 citations

An Immunomodulatory Function for Neutrophils During the Induction of a CD4+ Th2 Response in BALB/c Mice Infected withLeishmania major

2000 • 289 citations

Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice

1993 • 277 citations

IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

1998 • 274 citations

Neutrophils Play a Protective Nonphagocytic Role in SystemicMycobacterium tuberculosisInfection of Mice

2000 • 268 citations

Induction of MHC class II on human polymorphonuclear neutrophils by granulocyte/macrophage colony-stimulating factor, IFN-gamma, and IL-3.

1993 • 252 citations

Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection.

1994 • 242 citations

Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway

1997 • 236 citations

Rapid Recruitment of Neutrophils Containing Prestored IL-12 During Microbial Infection

2000 • 223 citations

Infectious Diseases of the Fetus and New-born Infant

1977 • 205 citations

Critical roles of neutrophils in host defense against experimental systemic infections of mice by Listeria monocytogenes, Salmonella typhimurium, and Yersinia enterocolitica

1997 • 203 citations

Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii

1997 • 197 citations

An immunoregulatory role for neutrophils in CD4+ T helper subset selection in mice with candidiasis.

1997 • 194 citations

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice.

1997 • 183 citations

Human polymorphonuclear leukocytes produce IL-12, TNF-alpha, and the chemokines macrophage-inflammatory protein-1 alpha and -1 beta in response to Toxoplasma gondii antigens.

1999 • 174 citations

CD4+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage.

1992 • 171 citations

Activation of Human T Cells by Major Histocompatability Complex Class II Expressing Neutrophils: Proliferation in the Presence of Superantigen, But Not Tetanus Toxoid

1997 • 152 citations

Decreased Resistance of TNF Receptor p55- and p75-Deficient Mice to Chronic Toxoplasmosis Despite Normal Activation of Inducible Nitric Oxide Synthase In Vivo

1998 • 145 citations

Release of tumor necrosis factor by human polymorphonuclear leukocytes

1990 • 144 citations

Human Polymorphonuclear Leukocytes Produce IL-12, TNF-α, and the Chemokines Macrophage-Inflammatory Protein-1α and -1β in Response toToxoplasma gondiiAntigens

1999 • 141 citations

Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12.

1999 • 125 citations

Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria

2000 • 120 citations

Murine Neutrophil Stimulation byToxoplasma gondiiAntigen Drives High Level Production of IFN-γ-Independent IL-12

1999 • 103 citations

Role of neutrophils in controlling early stages of a Chlamydia trachomatis infection

1996 • 103 citations

A protective role for IL‐6 during early infection with Toxoplasma gondii

1998 • 99 citations

Macrophage Inflammatory Protein-1α Is a Critical Mediator of Host Defense Against Invasive Pulmonary Aspergillosis in Neutropenic Hosts

2000 • 90 citations

Immunoregulation during Toxoplasmosis

1998 • 81 citations

Initiation of T-Helper Cell Immunity to Candida albicans by IL-12: The Role of Neutrophils

1997 • 75 citations

IL-10 Is Required for Development of Protective Th1 Responses in IL-12-Deficient Mice uponCandida albicansInfection

1998 • 73 citations

Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF-alpha and early death in C57BL/6 mice.

1999 • 71 citations

Exacerbation of toxoplasmosis in neutrophil-depleted mice.

1996 • 70 citations

Polymorphonuclear Neutrophils Are Necessary for the Recruitment of CD8⁺T Cells in the Liver in a Pregnant Mouse Model ofChlamydophila abortus(Chlamydia psittaciSerotype 1) Infection

2000 • 61 citations

Migration of Neutrophils From Lung to Tracheobronchial Lymph Node

1987 • 59 citations

Toxoplasma gondii and Schistosoma mansoni Synergize to Promote Hepatocyte Dysfunction Associated with High Levels of Plasma TNF-α and Early Death in C57BL/6 Mice

1999 • 52 citations

The crucial role of granulocytes in the early host defense against Strongyloides ratti infection in mice

2000 • 32 citations

Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii

1996 • 32 citations

A novel high-purity isolation method for human peripheral blood neutrophils permitting polymerase chain reaction-based mRNA studies

1999 • 27 citations

The molecular basis of T cell differentiation

1999 • 26 citations