Oxygen Sensing: Getting Pumped by Sterols

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 • 5,255 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O ₂ Sensing

2001 • 4,537 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 • 2,481 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

2000 • 1,527 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1996 • 1,195 citations

Oxygen sensing and molecular adaptation to hypoxia

1996 • 1,187 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

2003 • 771 citations

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

2003 • 683 citations

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

2004 • 417 citations

SREBP Pathway Responds to Sterols and Functions as an Oxygen Sensor in Fission Yeast

2005 • 318 citations

The SREBP pathway — insights from insigs and insects

2003 • 317 citations

Functional dissection and sequence of yeast HAP1 activator

1989 • 309 citations

Hypoxic but not anoxic stabilization of HIF-1α requires mitochondrial reactive oxygen species

2002 • 256 citations

Oxygen Sensing and the Transcriptional Regulation of Oxygen-Responsive Genes in Yeast

1998 • 252 citations

Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

2005 • 247 citations

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803

2002 • 211 citations

The Role of Mitochondria in the Regulation of Hypoxia-inducible Factor 1 Expression during Hypoxia

2000 • 208 citations

Bcl-2 Family Members and Functional Electron Transport Chain Regulate Oxygen Deprivation-Induced Cell Death

2002 • 175 citations

Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes

1999 • 174 citations

Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation

2001 • 173 citations

Exposure of Yeast Cells to Anoxia Induces Transient Oxidative Stress

2002 • 140 citations

Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

2003 • 139 citations

CYP1 (HAP1) regulator of oxygen-dependent gene expression in yeast

1988 • 128 citations

Identification and Characterization of a Low Oxygen Response Element Involved in the Hypoxic Induction of a Family ofSaccharomyces cerevisiae Genes

2001 • 111 citations

MGA2 Is Involved in the Low-Oxygen Response Element-Dependent Hypoxic Induction of Genes in Saccharomyces cerevisiae

2001 • 91 citations

A Mechanism of Oxygen Sensing in Yeast

2003 • 77 citations

Regulation of hypoxic gene expression in yeast

1997 • 75 citations

Models for oxygen sensing in yeast: implications for oxygen-regulated gene expression in higher eucaryotes

1999 • 72 citations

Roles of Transcription Factor Mot3 and Chromatin in Repression of the Hypoxic Gene ANB1 in Yeast

2000 • 55 citations

Mga2p Processing by Hypoxia and Unsaturated Fatty Acids in Saccharomyces cerevisiae : Impact on LORE-Dependent Gene Expression

2002 • 50 citations

Rox1 mediated repression. Oxygen dependent repression in yeast.

2000 • 49 citations