Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders
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Abstract
References (161)
Neurogenesis in the adult human hippocampus
1998 • 6,181 citations
Précis ofThe neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system
1982 • 4,511 citations
The Emotional Brain: The Mysterious Underpinnings of Emotional Life
2004 • 4,130 citations
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
1965 • 3,421 citations
Subgenual prefrontal cortex abnormalities in mood disorders
1997 • 2,646 citations
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
1999 • 2,351 citations
STRESS AND HIPPOCAMPAL PLASTICITY
1999 • 2,023 citations
Hippocampal atrophy in recurrent major depression.
1996 • 1,884 citations
MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder
1995 • 1,567 citations
Mechanisms of emotional arousal and lasting declarative memory
1998 • 1,558 citations
Neuropsychopharmacology
1990 • 1,545 citations
Glial reduction in the subgenual prefrontal cortex in mood disorders
1998 • 1,497 citations
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
1984 • 1,490 citations
The Emotional Brain: The Mysterious Underpinnings of Emotional Life
1998 • 1,461 citations
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
1999 • 1,450 citations
5-HIAA in the Cerebrospinal Fluid
1976 • 1,430 citations
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
1998 • 1,386 citations
Basic Neurochemistry???Molecular, Cellular, and Medical Aspects
2006 • 1,374 citations
The role of corticotropin-releasing factor in depression and anxiety disorders
1999 • 1,371 citations
Neurogenesis in the Neocortex of Adult Primates
1999 • 1,268 citations
A functional anatomical study of unipolar depression
1992 • 1,266 citations
Cortical pathways to the mammalian amygdala
1998 • 1,245 citations
Neurotransmitter Transporters: Recent Progress
1993 • 1,089 citations
Comorbidity of DSM–III–R Major Depressive Disorder in the General Population: Results from the US National Comorbidity Survey
1996 • 1,057 citations
Emotion, motivation, and anxiety: brain mechanisms and psychophysiology
1998 • 1,002 citations
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
1994 • 904 citations
Extinction of emotional learning: Contribution of medial prefrontal cortex
1993 • 895 citations
Regional Cerebral Blood Flow Measured During Symptom Provocation in Obsessive-Compulsive Disorder Using Oxygen 15—Labeled Carbon Dioxide and Positron Emission Tomography
1994 • 888 citations
Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder
1987 • 855 citations
Psychopharmacology: The Fourth Generation of Progress
1995 • 842 citations
Stress and hippocampal neurogenesis
1999 • 799 citations
Fear and the brain: where have we been, and where are we going?
1998 • 779 citations
PSYCHONEUROENDOCRINOLOGY OF DEPRESSION
1998 • 659 citations
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
1994 • 657 citations
Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.
1995 • 656 citations
Neural plasticity to stress and antidepressant treatment
1999 • 638 citations
Corticotropin-releasing factor, norepinephrine, and stress
1999 • 623 citations
Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain
1975 • 599 citations
Textbook of psychopharmacology
1975 • 583 citations
Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance
1991 • 575 citations
Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims
1986 • 552 citations
The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions.
1996 • 547 citations
Are different parts of the extended amygdala involved in fear versus anxiety?
1998 • 547 citations
Anatomy of the Serotonergic Systema
1990 • 541 citations
Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology
1991 • 536 citations
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography
1998 • 507 citations
Functional Neuroimaging Studies of Depression: The Anatomy of Melancholia
1998 • 503 citations
The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders
1999 • 498 citations
Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin
1978 • 476 citations
Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
1995 • 470 citations
Role of the Serotonergic System in the Pathogenesis of Major Depression and Suicidal Behavior
1999 • 442 citations
Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression
1997 • 424 citations
5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome
1997 • 413 citations
Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression
1995 • 398 citations
The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
1997 • 397 citations
Enhancement of Imipramine Antidepressant Activity by Thyroid Hormone
1969 • 392 citations
The Revised Monoamine Theory of Depression: A Modulatory Role for Monoamines, Based on New Findings From Monoamine Depletion Experiments in Humans
1996 • 382 citations
Effect of clonidine on growth hormone release in psychiatric patients and controls
1980 • 377 citations
Early childhood predictors of adult anxiety disorders
1999 • 362 citations
The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress
1999 • 358 citations
Serotonin and Hallucinogens
1999 • 343 citations
The amygdala modulates prefrontal cortex activity relative to conditioned fear
1999 • 343 citations
Monoamine dysfunction and the pathophysiology and treatment of depression.
1998 • 341 citations
Catecholamine Metabolism, Depressive Illness, and Drug Response
1972 • 341 citations
Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.
1991 • 338 citations
Serotonin and Hippocampal Neurogenesis
1999 • 331 citations
Activity of Serotonergic Neurons in Behaving Animals
1999 • 315 citations
Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus
1988 • 314 citations
Monoamine Innervation of the Cerebral Cortex
1985 • 308 citations
Mental Depression in Hypertensive Patients Treated for Long Periods with Large Doses of Reserpine
1954 • 306 citations
Frontal and parietal metabolic disturbances in unipolar depression
1994 • 305 citations
Serotonergic Modulation of Neurotransmission in the Rat Basolateral Amygdala
1999 • 303 citations
An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat
1998 • 301 citations
Serotonin receptors in cognitive behaviors
1997 • 299 citations
The Locus Coeruleus as a Site for Integrating Corticotropin‐Releasing Factor and Noradrenergic Mediation of Stress Responsesa
1993 • 297 citations
Role of norepinephrine in the pathophysiology and treatment of mood disorders
1999 • 291 citations
Cerebrospinal Fluid Monoamine Metabolites and Suicidal Behavior in Depressed Patients
1989 • 281 citations
Applied Therapeutics. The Clinical Use of Drugs
1990 • 275 citations
Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors
1999 • 269 citations
Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity?
1993 • 265 citations
Role of norepinephrine in depression.
2000 • 251 citations
Resting Plasma Catecholamine Concentrations in Patients With Depression and Anxiety
1971 • 249 citations
Serotonin and Stress
1999 • 248 citations
Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei
1993 • 239 citations
The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias
1999 • 237 citations
Chapter 31 Networks related to the orbital and medial prefrontal cortex; a substrate for emotional behavior?
1996 • 227 citations
Quantitation of catecholamine neurons in the locus coeruleus in human brains of normal young and older adults and in depression
1989 • 226 citations
Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants
1993 • 210 citations
Norepinephrine and Its Metabolites in Cerebrospinal Fluid, Plasma, and Urine
1988 • 207 citations
Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus.
1990 • 203 citations
Down-regulation of β-adrenergic receptors following repeated injections of desmethylimipramine: Permissive role of serotonergic axons
1982 • 188 citations
Serotonin Neurons, Neuroplasticity, and Homeostasis of Neural Tissue
1999 • 182 citations
Desensitization of the neuronal 5-HT carrier following its long-term blockade
1994 • 182 citations
Serotonin and Hallucinogens
1999 • 175 citations
α2-Adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression
1992 • 171 citations
Brain 5-HT1 binding sites in depressed suicides
1990 • 165 citations
Fewer pigmented locus coeruleus neurons in suicide victims: Preliminary results
1996 • 163 citations
Depression and anxiety: Role of the locus coeruleus and corticotropin-releasing factor
1994 • 162 citations
Anatomic basis for differential regulation of the rostrolateral peri–locus coeruleus region by limbic afferents
1999 • 162 citations
Agonist Binding to α2‐Adrenoceptors Is Elevated in the Locus Coeruleus from Victims of Suicide
1994 • 160 citations
Neuropsychological dysfunction in depression: the relationship to regional cerebral blood flow
1994 • 158 citations
Association of Aggressive Behavior With Altered Serotonergic Function in Patients Who Are Not Suicidal
2000 • 156 citations
Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims
1991 • 153 citations
Serotonin Receptor Subtypes
1995 • 149 citations
New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain
1988 • 147 citations
Serotonin Modulation of Sensory Inputs to the Lateral Amygdala: Dependency on Corticosterone
1998 • 147 citations
Elevated Tyrosine Hydroxylase in the Locus Coeruleus of Suicide Victims
1994 • 146 citations
The functional anatomy, neurochemistry, and pharmacology of anxiety.
1999 • 141 citations
The Excitatory Effects of the Amygdala on Hypothalamo-Pituitary-Adrenocortical Responses Are Mediated by Hypothalamic Norepinephrine, Serotonin, and CRF-41
1998 • 136 citations
Blunted Serotonergic Responsivity in Depressed Inpatients
1995 • 136 citations
Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour
1998 • 136 citations
A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation
1990 • 133 citations
Coordinate Regulation of the Cyclic AMP System with Firing Rate and Expression of Tyrosine Hydroxylase in the Rat Locus Coeruleus: Effects of Chronic Stress and Drug Treatments
1992 • 133 citations
Presynaptic Adrenergic Receptor Sensitivity in Depression
1981 • 133 citations
The time course of noradrenergic pre- and postsynaptic activity during chronic desipramine treatment
1980 • 132 citations
Noradrenergic function in generalized anxiety disorder, major depressive disorder, and healthy subjects
1989 • 122 citations
Modulation of 5‐HT release in the guinea‐pig brain following long‐term administration of antidepressant drugs
1994 • 120 citations
Blunted Growth Hormone Response to Clonidine in Patients With Generalized Anxiety Disorder
1991 • 118 citations
Selective Antidepressants and Cerebrospinal Fluid
1985 • 117 citations
The role of noradrenaline in depression: a review.
1997 • 101 citations
Marked Reduction in the Number of Platelet—Tritiated Imipramine Binding Sites in Geriatric Depression
1988 • 100 citations
Studies of a neurochemical link between depression, anxiety, and stress from [3H]imipramine and [3H]paroxetine binding on human platelets
1994 • 95 citations
Studies on the serotonin uptake binding site in major depressive disorder and control post-mortem brain: Neurochemical and clinical correlates
1991 • 93 citations
Generalized anxiety disorder: neurobiological and pharmacotherapeutic perspectives
1998 • 93 citations
The DST in psychiatric outpatients with generalized anxiety disorder, panic disorder, or primary affective disorder
1985 • 90 citations
Anatomic and Physiologic Substrates of Emotion in an Animal Model
1998 • 89 citations
Brain β-adrenoceptor binding sites in antidepressant-free depressed suicide victims
1990 • 88 citations
Comparison of the effects of repeated electroconvulsive shock on α2- and β-adrenoceptors in different regions of rat brain
1982 • 85 citations
Electrophysiological characterization of 5-hydroxytryptamine2 receptors in the rat medial prefrontal cortex.
1990 • 85 citations
Serotonin attenuates a slow inhibitory postsynaptic potential in rat hippocampal neurons
1990 • 85 citations
Serotonin function and depression: neuroendocrine and mood responses to intravenous L-tryptophan in depressed patients and healthy comparison subjects
1991 • 83 citations
Altered platelet serotonin uptake kinetics in schizophrenia and depression
1982 • 81 citations
Monoaminergic fibers form conventional synapses in the cerebral cortex
1987 • 80 citations
Long-Term Stress Degenerates, But Imipramine Regenerates, Noradrenergic Axons in the Rat Cerebral Cortex
1997 • 79 citations
Electrophysiological characterization of adrenoceptors in the rat dorsal hippocampus. I. Receptors mediating the effect of microiontophoretically applied norepinephrine
1988 • 70 citations
Suppressant effects of dexamethasone on the availability of plasma L‐tryptophan and tyrosine in healthy controls and in depressed patients
1990 • 67 citations
Cerebrospinal fluid monoamine metabolites in fluoxetine-treated patients with major depression and in healthy volunteers
1993 • 66 citations
Plasma MHPG in depressive disorders and relationship to the dexamethasone suppression test
1986 • 66 citations
The growth hormone response to clonidine in acute and remitted depressed male patients.
1992 • 63 citations
Molecular and cellular mechanisms of antidepressant drugs
1996 • 62 citations
EFFECT OF CHRONIC TREATMENT WITH TRICYCLIC ANTIDEPRESSANT DRUGS ON IDENTIFIED BRAIN NORADRENERGIC AND SEROTONERGIC NEURONS
1980 • 62 citations
Degeneration of locus coeruleus axons in stress-induced depression model
1994 • 59 citations
Recovery from Major Depression Is Not Associated with Normalization of Serotonergic Function
1998 • 59 citations
D-fenfluramine-induced prolactin and cortisol release in major depression: Response to treatment
1992 • 58 citations
Biology of schizophrenia and affective disease
1997 • 58 citations
Comparison of [3H]Paroxetine and [3H]Cyanoimipramine for Quantitative Measurement of Serotonin Transporter Sites in Human Brain
1996 • 58 citations
Hormone responses to fenfluramine and placebo challenge in endogenous depression
1992 • 57 citations
Alterations in Monoamine Receptors in the Brain of Suicide Victims
1992 • 55 citations
Corticotropin-Releasing Factor Concentrations Exhibit an Apparent Diurnal Rhythm in Hypothalamic and Extrahypothalamic Brain Regions: Differential Sensitivity to Corticosterone
1990 • 48 citations
Hypothalamic-pituitary-adrenal axis activity in panic disorder: prediction of long-term outcome by pretreatment cortisol levels
1996 • 42 citations
Platelet 5-HT uptake sites in depression: three concurrent measures using [3H] imipramine and [3H] paroxetine
1993 • 42 citations
The dexamethasone suppression test and plasma dexamethasone in generalized anxiety disorder
1988 • 41 citations
The neurobiological basis of mixed depression-anxiety states.
1993 • 37 citations
Sources of Variance in Clinical Studies of MHPG
1983 • 37 citations
Distribution of [3H]Citalopram Binding Sites in the Nonhuman Primate Brain
1999 • 30 citations
Metabolic rate in the amygdala predicts negative affect and depression severity in depressed patients: An FDG-PET study
1996 • 27 citations
MMPI measures of impulsivity and depression correlate with CSF 5-HIAA and HVA in depression but not schizophrenia
1991 • 25 citations
Noradrenergic Function in Depressive Disorders
1993 • 22 citations
Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites.
1989 • 21 citations
Effects of Pharmacological Agents on MHPG
1983 • 18 citations
Antidepressants affect amine modulation of neurotransmission in the rat hippocampal slice—I. Delayed effects
1991 • 17 citations