Noradrenergic Function in Depressive Disorders

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Development of β-adrenergic receptor subsensitivity by antidepressants

1977 • 727 citations

Catecholamine metabolism: basic aspects and clinical significance.

1985 • 589 citations

Increased Serotonin2 and β-Adrenergic Receptor Binding in the Frontal Cortices of Suicide Victims

1986 • 552 citations

Mode of action of antidepressant drugs

1978 • 514 citations

Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla

1987 • 444 citations

Circadian Rhythms of Epinephrine and Norepinephrine in Man*

1985 • 386 citations

Catecholamine Metabolism, Depressive Illness, and Drug Response

1972 • 341 citations

Psychopharmacology: A Generation of Progress

1978 • 310 citations

SEASONAL AND CIRCADIAN MONOAMINE VARIATIONS IN HUMAN BRAINS EXAMINED POST MORTEM

1980 • 303 citations

Abnormal Regulation of Noradrenergic Function in Panic Disorders

1986 • 301 citations

Biological Markers in Psychiatry and Neurology

1982 • 285 citations

Effect of electroconvulsive shock on monoaminergic receptor binding sites in rat brain

1979 • 276 citations

Adrenergic Receptor Sensitivity in Depression

1982 • 253 citations

Plasma dihydroxyphenylglycol and the intraneuronal disposition of norepinephrine in humans.

1988 • 245 citations

Toward a Biochemical Classification of Depressive Disorders

1978 • 217 citations

Urinary 3-Methoxy-4-Hydroxyphenylglycol Circadian Rhythm

1980 • 197 citations

The Peripheral Kinetics of Norepinephrine in Depressive Illness

1982 • 193 citations

Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls

1982 • 190 citations

Regionally selective increases in μ opioid receptor density in the brains of suicide victims

1990 • 171 citations

The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem

1989 • 167 citations

Dysphoric Mania

1989 • 164 citations

Reduced Sensitivity of Lymphocyte Beta-Adrenergic Receptors in Patients with Endogenous Depression and Psychomotor Agitation

1985 • 157 citations

Monoamine-related markers of depression: Changes following treatment

1982 • 153 citations

Altered Central α2-Adrenoceptor Sensitivity in Panic Disorder

1989 • 152 citations

Depression and MHPG Excretion

1972 • 150 citations

An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla

1986 • 140 citations

Biochemical and Functional Evidence of Supersensitive Platelet α2-Adrenoceptors in Major Affective Disorder

1986 • 140 citations

Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 139 citations

Beta-adrenergic receptor function in affective illness

1979 • 130 citations

α2-adrenoreceptors on human platelets: Selective labelling by [3H]clonidine and [3H]yohimbine and competetive inhibition by antidepressant drugs

1981 • 117 citations

Studies on possible mechanisms of action of electroconvulsive therapy; effects of repeated electrically induced seizures on rat brain receptors for monoamines and other neurotransmitters

1981 • 117 citations

Changes in lymphocyte beta-adrenergic receptors in depression and mania

1979 • 117 citations

Blunted growth hormone response to clonidine in panic disorder patients

1986 • 105 citations

Exaggerated Orthostatic Responsivity of Plasma Norepinephrine in Depression

1985 • 101 citations

Regionally selective increases in β-adrenergic receptor density in the brains of suicide victims

1988 • 96 citations

Subtypes of Depression Based on Excretion of MHPG and Response to Nortriptyline

1980 • 93 citations

Growth Hormone Response to Clonidine in Obsessive-Compulsive Patients

1983 • 88 citations

Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls

1984 • 88 citations

Urinary MHPG in Subgroups of Depressed Patients and Normal Controls

1980 • 86 citations

Effects of oral clonidine on plasma 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) in man: Preliminary report

1980 • 80 citations

α2-adrenergic receptors in platelet membranes of depressed patients: No change in number of 3H-yohimbine affinity

1981 • 77 citations

Pre-treatment neurotransmitter metabolites and response to imipramine or amitriptyline treatment

1982 • 75 citations

Peripheral adrenoceptors and serotonin receptors in depression

1985 • 75 citations

α2-Adrenoceptor—Mediated Inhibition of Platelet Adenylate Cyclase and Induction of Aggregation in Major Depression

1990 • 75 citations

Plasma Cortisol Responses to Clonidine in Depressed Patients and Controls

1984 • 75 citations

Platelet α2-Adrenergic Receptors in Depression

1986 • 71 citations

Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors.

1990 • 70 citations

Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy

1983 • 69 citations

Differential inhibitory noradrenergic responses to clonidine in 25 depressed patients and 25 normal control subjects

1984 • 69 citations

Toward a Biochemical Classification of Depressive Disorders

1989 • 67 citations

Evidence for the existence of a homogenous population of imidazoline receptors in the human brainstem

1988 • 67 citations

Plasma MHPG in depressive disorders and relationship to the dexamethasone suppression test

1986 • 66 citations

Frontiers in Neuropsychiatric Research

1983 • 65 citations

Blunted β-Adrenergic Responsivity of Peripheral Blood Mononuclear Cells in Endogenous Depression

1988 • 63 citations

Estrogen Treatment Decreases a-Adrenergic Binding Sites on Rabbit Platelets*

1979 • 60 citations

Evaluation of studies on platelet alpha2 adrenoreceptors in depressive illness

1986 • 59 citations

MHPG as a predictor of antidepressant response to imipramine and maprotiline

1980 • 57 citations

Platelet alpha2-adrenergic receptor sensitivity in major depressive disorder

1983 • 57 citations

Cyclic AMP Second-Messenger Signal Amplification in Depression

1988 • 53 citations

Adrenergic Receptors in Depression

1985 • 52 citations

β‐Adrenoceptor binding defects in cell lines from families with manic‐depressive disorder

1984 • 50 citations

Primary Affective Disorder, Clinical State Change, and MHPG Excretion

1978 • 48 citations

Multiple hormone responses to clonidine administration in depressed patients and healthy volunteers

1989 • 47 citations

Increased 3H-Clonidine binding in the platelets of patients with depressive and Schizophrenic disorders

1989 • 42 citations

Lymphocyte beta-adrenoreceptor density in patients with unipolar depression and normal controls

1989 • 41 citations

The Diurnal Variation in Plasma Homovanillic Acid Level Persists but the Variation in 3-Methoxy-4-hydroxyphenylglycol Level Is Abolished Under Constant Conditions

1988 • 41 citations

Characterization of platelet alpha2 adrenoceptors and measurement in control and depressed subjects

1985 • 39 citations

Avenues of Investigation for the Role of Catecholamines in Anxiety

1984 • 39 citations

Platelet alpha 2-adrenoreceptor binding in elderly depressed patients

1985 • 37 citations

Effect of Ganglion Blockade on Cerebrospinal Fluid Norepinephrine

1987 • 35 citations

Clinical studies on norepinephrine metabolism: How to interpret the numbers

1986 • 35 citations

Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients

1987 • 32 citations

Covariance of plasma free 3-methoxy-4-hydroxyphenethyleneglycol and diastolic blood pressure

1981 • 31 citations

Plasma concentrations of noradrenaline and 3,4-dihydroxyphenylethyleneglycol under conditions of enhanced sympathetic activity

1988 • 30 citations

Studies on leukocyte β-adrenergic receptors in depression: A critical appraisal

1990 • 28 citations

Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders

1986 • 27 citations

Alpha2-adrenergic receptors in platelet membranes of depressed patients: Increased affinity for 3H-yohimbine

1987 • 26 citations

Effects of desipramine on diurnal rhythms of plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) in depressed patients.

1982 • 26 citations

Biological markers in juvenile depression

1988 • 25 citations

Normalization of Blunted Lymphocyte β-Adrenergic Responsivity in Melancholic Inpatients by a Course of Electroconvulsive Therapy

1990 • 21 citations

Enhanced α2-adrenoceptor-mediated platelet aggregation in patients with major depressive disorder

1983 • 21 citations

The evaluation of 4-hydroxy-3-methoxyphenylglycol sulfate as a possible marker of central norepinephrine turnover. Studies in healthy volunteers and depressed patients

1988 • 21 citations

Platelet Radioligand Binding and Neuroendocrine Challenge Tests in Depression

2007 • 21 citations

Diurnal rhythm of 3-methoxy-4-hydroxyphenylglycol (MHPG); relationship between plasma and urinary levels

1985 • 20 citations

[3H]Yohimbine binding to platelet α2-adrenoceptors in depression

1989 • 18 citations

Studies of beta-adrenergic receptors in leukocytes of patients with affective illness and effects of antidepressant drugs.

1985 • 17 citations

Failure of urinary MHPG levels to predict treatment response in patients with unipolar depression

1986 • 15 citations

Platelet α 2-adrenoceptors in major depression: relationship with urinary 4-hydroxy -3- methoxyphenylglycol and age at onset

1985 • 15 citations

Platelet ∝2-adrenergic receptor activity in clinical studies of depression

1983 • 15 citations

Enhanced histamine- and β-adrenoceptor-mediated cyclic AMP formation in leukocytes from patients with endogenous depression

1987 • 15 citations

Lymphocyte beta adrenergic receptor function versus catecholamines in depression

1988 • 14 citations

The response of lymphocyte beta-adrenergic receptors to chronic propranolol treatment in depressed patients, schizophrenic patients, and normal controls.

1983 • 13 citations

α-Adrenoceptor Changes after Oestrogen Treatment in Platelets and other Tissues in Female Rabbits

1985 • 12 citations

Identification of a homogeneous class of beta 2-adrenoceptors in human platelets by (-)-125I-iodopindolol binding.

1985 • 12 citations

Alpha2-adrenergic receptor sensitivity in depressed patients: Relation between 3H-yohimbine binding to platelet membranes and clonidine-induced hypotension

1989 • 11 citations

The Catecholaminergic Response to Stress and Exercise

1985 • 10 citations

Catecholamine measures for diagnosis and treatment of patients with depressive disorders.

1980 • 10 citations

Biochemical Classifications of Diagnostic Subgroups and D-Type Scores

1989 • 9 citations

Biogenic monoamines and their metabolites in the urine, plasma, and cerebrospinal fluid of normal, psychiatric, and neurological subjects

1990 • 8 citations

Drs. Janicak and Davis Reply

1986 • 7 citations

The effects of sexual maturation on α-adrenoceptors in female rabbits

1985 • 7 citations

Lower cortical beta-adrenoceptor binding sites in post-mortem samples from depressed suicide victims.

1989 • 6 citations

Deleted Work

1955 • 0 citations