Cloning and Expression of the cDNA for aDrosophilaInsulin-Degrading Enzyme

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates

1987 • 966 citations

Codon usage tabulated from the GenBank Genetic Sequence Data

1988 • 608 citations

Comparison of human stromelysin and collagenase by cloning and sequence analysis

1986 • 443 citations

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1989 • 348 citations

The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats

1987 • 317 citations

Three-dimensional Structure of Thermolysin

1972 • 292 citations

slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

1988 • 281 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

Amino-acid Sequence of Thermolysin

1972 • 251 citations

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA

1988 • 241 citations

Crystallographic study of the binding of dipeptide inhibitors to thermolysin: implications for the mechanism of catalysis

1977 • 240 citations

Amino acid sequence of rabbit kidney neutral endopeptidase 24.11 (enkephalinase) deduced from a complementary DNA.

1987 • 238 citations

Molecular characterization and nucleotide sequence of the Pseudomonas aeruginosa elastase structural gene

1988 • 232 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

Cloning and sequencing ofSerratiaprotease gene

1986 • 184 citations

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

1989 • 174 citations

Structure of Thermolysin

1972 • 163 citations

Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin

1989 • 152 citations

Human Insulin-Degrading Enzyme Shares Structural and Functional Homologies with E. coli Protease III

1988 • 141 citations

THE AMINO ACID SEQUENCE OF BOVINE CARBOXYPEPTIDASE A

1969 • 140 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila

1983 • 124 citations

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

1986 • 118 citations

Nucleotide sequences of the drosophila src and abl homologs: conservation and variability in the src family oncogenes

1983 • 114 citations

Amino acid sequence of a unique protease from the crayfish Astacus fluviatilis

1987 • 108 citations

Insulin in Insects and Annelids

1981 • 107 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Degradation products of insulin generated by hepatocytes and by insulin protease.

1988 • 95 citations

A high molecular weight metalloendoprotease from the cytosol of mammalian cells.

1983 • 93 citations

Purification and characterization of protease III from Escherichia coli.

1979 • 88 citations

Acquisition of insulin-dependent protein tyrosine kinase activity during Drosophila embryogenesis.

1985 • 87 citations

Complete nucleotide sequence of theEscherichia coli ptrgene encoding Protease III

1986 • 81 citations

Amino-acid sequence of bovine carboxypeptidase B.

1975 • 81 citations

Insulin-Degrading Enzyme: Stable Expression of the Human Complementary DNA, Characterization of its Protein Product, and Chromosomal Mapping of the Human and Mouse Genes

1990 • 69 citations

A Drosophila genomic sequence with homology to human epidermal growth factor receptor

1985 • 66 citations

Attenuated Processing of Epidermal Growth Factor in the Face of Marked Degradation of Transforming Growth Factor-α

1989 • 56 citations

Metalloendoprotease Inhibitors Which Block the Differentiation of L6 Myoblasts Inhibit Insulin Degradation by the Endogenous Insulin-degrading Enzyme

1989 • 54 citations

The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis.

1988 • 54 citations

An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.

1989 • 53 citations

Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster

1988 • 42 citations

Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites

1989 • 31 citations

Supercoiled plasmid sequencing one buffer for template denaturation, primer annealing, and synthesis of labeled strands by reverse transcriptase

1986 • 22 citations

An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.

1989 • 17 citations